MRP基因表达对NSCLC术后化疗的影响  

Effects of MRP Gene mRNA Overexpression on Chemotherapy Efficacy in NSCLC

作　　者：钟竑[1] 单根法[1] 张辅贤[1] 李国庆[1] 隆桂麟[1] 顾鹤定[1] 

机构地区：[1]上海第二医科大学新华医院心胸外科,上海200092

出　　处：《上海第二医科大学学报》2000年第3期248-249,264,共3页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市自然科学基金资助课题 !(96ZB1 4 0 4 3)

摘　　要：探讨多药耐药性相关蛋白基因——MRP基因 (multi-drugresistanceassociatedproteingene)对肺癌患者术后化疗疗效的影响。　方法应用原位分子杂交结合免疫组化技术检测 35例非小细胞肺癌 (NSCLS)根治术后化疗患者石蜡组织标本中肺癌细胞MRP基因mRNA表达 ,并回顾性随访。　结果 35例NSCLC患者肺癌细胞均有不同程度的MRP基因mRNA表达 ,其表达水平与术后化疗疗效密切相关。　结论MRP基因mRNA表达水平与肺癌患者术后化疗疗效有密切相关性 ,检测MRP基因mRNA表达水平可预测肺癌患者化疗疗效。Objective Study the effect of MRP gene (Multi-drug resistance associated protein gene, MRP gene) mRNA overexpression to chemotherapy of lung cancer patients after surgery. Methods Paraffin embedded tissues from 35 cases suffered from non-small cell lung cancer (NSCLC) who was treated with radical resection and chemotherapy. After operation determination for expression of MRP gene mRNA by in situ hybridisation combined with immunohistochemistry was done. All the patients were followed up. Results All of 35 lung cancer tissues were found to have overexpression of MRP gene mRNA and it were obviously associated with the effects of chemotherapy after surgery. Conclusion MRP gene were associated with the effects of post-operative chemotherapy in lung cancer patients and may be regarded as a mean to forecast the effects of chemotherapy in lung cancer patients.

关 键 词：肺癌 耐药性 MRP基因 NSCLC 药物疗法 

分 类 号：R730.5[医药卫生—肿瘤]