JWA基因多态性与紫杉类药物对晚期胃癌化疗疗效相关性的研究  

Research on the relationship between polymorphisms of gene JWA and curative effect of gastric chemotherapy with taxane medicine in advanced gastric cancer

作　　者：汤唯艳[1] 宋雪[2] 朱立伟[2] 李小优[1] 吴剑秋[1] 吴建中[2] 冯继锋[1] 

机构地区：[1]江苏省肿瘤医院内科,江苏南京210009 [2]江苏省肿瘤医院临床肿瘤实验中心,江苏南京210009

出　　处：《实用临床医药杂志》2012年第23期12-14,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11220245)

摘　　要：目的探讨JWA基因723T>G和454A>C多态性位点与含紫杉类药物对胃癌患者化疗疗效的相关性。方法 64例晚期胃癌患者给予含紫杉类药物方案治疗,化疗前检测723和454基因型。观察化疗疗效与723和454位点多态性的关系。结果本组胃癌患者总的化疗疾病控制率为73.4%,且发现与723TT基因型相比,携带723TG/GG基因型者能够显著降低胃癌疾病进展,但是没有发现454 A>C多态性与胃癌化疗疗效相关性具有统计学差异。结论 JWA基因723T>G多态性位点与晚期胃癌对紫杉类药物的化疗疗效相关性有关联,携带G等位基因型的胃癌患者具有较高的疾病控制率,提示JWA多态性可能成为预测胃癌化疗疗效的指标之一。Objective To explore the relationship between polymorphisms of JWA 723T〉 G and 454A 〉 C and curative effect of taxanes - based chemotherapy in advanced gastric cancer. Methods 64 advanced gastric cancer patients were treated with taxanes- based chemotherapy, and the genotypes of 723 and 454 were detected before the therapy. The relationship between the chemotherapy effect and genetic polymorphisms of JWA 723 and 454 were observed. Results The chemotherapy control rate of this group was 73.4 %, and the differences were statistically signifi- cant. There was no significant difference on efficiency rate among different genotype of JWA 454. Conclusion 723T 〉G polymorphism has some correlation with the curative effect of Taxanes- based chemotherapy in advanced gastric cancer, the gastric cancer patients with G allelotype have a higher rate in controlling disease, which means JWA polymorphisms may be an important index in predicting the chemotherapeutic effect for gastric cancer.

关 键 词：胃癌 JWA基因多态性 紫杉类 化疗疗效 相关性 

分 类 号：R735.2[医药卫生—肿瘤]