^(18)F-FDG PET-CT对滤泡性淋巴瘤诊断及预后评估的作用  

Diagnostic and prognostic evaluation of ^(18)F-FDG PET/CT in follicular lymphoma

作　　者：孟祥睿[1] 王华庆[1] 任旭升[1] 张会来[1] 钱正子[1] 周世勇[1] 

机构地区：[1]天津医科大学附属肿瘤医院淋巴肿瘤科天津市肿瘤防治重点实验室中美淋巴瘤血液诊治中心,天津300060

出　　处：《中国实验诊断学》2012年第12期2239-2242,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的评估18氟-氟代脱氧葡萄糖-正电子发射计算机断层显像(fluorine-18fluorodeoxyglucose positron e-mission tomography,18F-FDG PET/CT)对滤泡性淋巴瘤(follicular lymphoma,FL)患者的诊断及预后的预测价值。方法回顾分析2005年4月至2009年7月我院收治67例初治滤泡性淋巴瘤患者,分别与6周期CHOP±R方案化疗前后行PET/CT检查,评价其对临床分期及预后评估的价值。结果 PET/CT对初始分期准确度较CT高,可获得更精确的FLIPI评分。6周期治疗结束后PET/CT阴性者与阳性者的中位PFS分别为45个月及19个月(P=0.0007),显示治疗后PET/CT检查结果为患者预后的预测指标。结论 PET-CT是FL明确分期及预后评估的可靠方法。Objective To assess the evaluation of positron emission tomography/computed tomography in staging and prognosis in follicular lymphoma.Methods A retrospective study was performed on 67 patients with untreated biopsy-proven follicular lymphoma who underwent 18F-fluorodeoxygulucose PET/CT（FDG PET/CT） before and after CHOP±R induction treatment from April 2005 to July 2009.Results Initial PET/CT makes Follicular Lymphoma International Prognostic Index score more accurately than CT.In addition,post-treatment PET/CT was able to predict patients＇ outcomes.The median progression-fress survival was 45 months in the PET/CT negative group as compared with 19months for the group with residual uptake（P=0.0007）.Conclusion PET/CT is useful for staging and assessing the prognosis of patients with follicular lymphoma.

关 键 词：滤泡性淋巴瘤 18氟-氟代脱氧葡萄糖 正电子发射计算机断层显像 预后 

分 类 号：R733.1[医药卫生—肿瘤]