恶性肿瘤及感染性疾病患者血清sMICA分子的变化及意义  

The Changes and Significance of Serum sMICA Protein in Patients with Malignant Tumor or Infectious Diseases

作　　者：姜孝新[1,2] 蒋艳[1] 谢小平[1] 李艳雯[1] 伍小平[1] 霍治[2] 

机构地区：[1]南华大学附属第一医院,湖南衡阳421001 [2]中南大学基础医学院,湖南长沙410013

出　　处：《肿瘤药学》2012年第6期411-416,442,共7页Anti-Tumor Pharmacy

基　　金：国家自然基金项目资助(31200141);湖南省教育厅项目资助(11C1110)

摘　　要：目的研究恶性肿瘤患者以及不同感染性疾病患者血清中sMICA分子的含量及临床意义。方法采用ELISA法检测1041例恶性肿瘤及感染性疾病患者和141例正常对照个体血清sMICA分子含量,分析其相关性及诊断价值。结果与正常对照组相比,肝癌患者的血清sMICA含量明显升高(P<0.05)。某些细菌(肠杆菌、结核杆菌、非发酵革兰阴性菌和革兰阳性球菌)、病毒(HBV和HCV)以及梅毒螺旋体感染患者的血清sMICA含量也明显高于正常对照组(P<0.05)。结论血清中sMICA分子含量对肝癌及部分感染性疾病具有一定的辅助诊断价值。肠杆菌、结核杆菌、非发酵革兰阴性菌、革兰阳性球菌、HBV、HCV及梅毒螺旋体感染可导致血清sMICA分子增高。Objective To identify the levels of serum soluble major histocompatibility complex class I chain-related gene A （sMICA） protein in patients with malignant minor/infectious diseases and explore its clinical significance. Methods The serum sMICA levels were determined by enzyme-linked immunosorbent assay （ELISA）, including patients （n=1041） suffering from several types of malignant tumors and infectious diseases and healthy controls （n=141）. The correlation and diagnostic value were analyzed. Results Compared with the controls, serum sMICA elevation was significantly increased in patients of hepatic cancer （P 〈 0.05）. The sMICA levels of patients with bacterial （Enterobacteriaceae, Mycobacterium tuberculosis, non-ferment- ing Gram-negative bacteria and Gram-positive cocci）, viral （hepatitis B and C） and the Microspironema pallidum infections were also significantly higher than that of the controls （P〈 0.05）. Conclusion Serum sMICA levels may be informative for the diagnosis of hepatic cancer and some infectious diseases. Serum sMICA elevation may be caused by Enterobacteriaceae, Myco- bacterium tuberculosis, non-fermenting Gram-negative bacteria, Gram-positive cocci, HBV, HCV and the Microspironema pallidum.

关 键 词：MICA SMICA 感染 恶性肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]