自发性蛛网膜下腔出血后脑血管痉挛节律特征的研究  

Study of rhythmical characteristic for cerebral vasospasm after spontaneous subarachnoid hemorrhage

作　　者：吴科[1] 魏剑波[1] 张月辉[1] 彭燕[1] 黄志刚[1] 鄢克坤 

机构地区：[1]攀枝花市中心医院神经疾病中心,四川攀枝花617067

出　　处：《四川生理科学杂志》2012年第4期155-157,共3页Sichuan Journal of Physiological Sciences

基　　金：攀枝花市科学技术和知识产权局提供经费支持(编号:100352)

摘　　要：目的:探讨分析自发性蛛网膜下腔出血后脑血管痉挛的生物节律特征。方法:选取87例经头颅CT、CTA、DSA及脑血管彩超确诊为蛛网膜下腔出血并发脑血管痉挛患者,在自然光暗循环条件下利用经颅多普勒(Transcranial Dopplor,TCD)对患者大脑中动脉平均血流速度(Vm)进行24小时以上连续监测后判断分析24小时12个时间段的发病时间特征。结果:8∶00点和20∶00点两个时间点的大脑中动脉平均血流速度较其他时间点有显著性差异,流速显著较快(P<0.05),脑血管痉挛的节律变化特征呈"双峰"表现。结论:自发性蛛网膜下腔出血后脑血管痉挛时间具有典型的近日节律特征,其发病高峰期位于每日的8∶00点及20∶00点。Objective： Characteristics of biological rhythms for cerebral vasospasm after spontaneous subarachnoid hemorrhage were analyzed. Methods. 87 cases of subarachnoid hemorrhage complicated with cerebral vasospasm were selected, which were definitively diagnosed by cranial CT, CTA, DSA and cerebral vascular ultrasound. Middle cerebral artery mean blood velocity （Vm） was detected consecutively by transcranial Doppler （Transcranial Dopplor, TCD） in the natural light-dark cycle. Characteristics of 12 time-points when SAH was onset were analyzed. Results; Vm at Two time-points, 8 ： 00 and 20 ： 00, were significant difference （P〈0. 05） and these two mean Vm were faster than others. The feature of cerebral vasospasm circadian rhythm was bimodal. Conclusion： Spontaneous subarachnoid hemorrhage vasospasm time has typical circadian rhythms and peak incidences in the daily were at 8： 00and20：00.

关 键 词：自发性蛛网膜下腔出血 脑血管痉挛 TCD 近日节律 

分 类 号：R743.3[医药卫生—神经病学与精神病学]