核因子E2相关因子2抗氧化反应元件通路在血管中的表达  

Expression of the nuclear factor erythroid 2-related factor 2-antioxidant response element pathway in the vascular system

作　　者：吴琪[1] 张鑫[1] 王汉东[1] 

机构地区：[1]南京军区南京总医院神经外科

出　　处：《医学研究生学报》2012年第12期1308-1310,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81070974)

摘　　要：核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)信号通路由转录因子Nrf2、调控蛋白Keap1以及抗氧化反应元件(antioxidant response element,ARE)组成,调节ARE下游包括氧化还原蛋白、二相解毒酶、转运蛋白等超过200种基因的表达,是介导抗氧化反应的关键信号途径。近年来,研究发现Nrf2通路有血管保护作用,文中就其在血管中的表达及意义进行综述。Consisting of the transcription factor Nrf2, keapl and antioxidant response element, the Nrf2 signaling pathway plays an important role in antioxidant response via regulating more than 200 kinds of Nrf2 downstream genes, such as redox-balaneing proteins, phase Ⅱ detoxifying enzymes, and transporters. It is recently reported that the Nrf2 signaling pathway can also protect the vascular system. This paper presents a review on the expression of the Nrf2 pathway in the vascular system and its significance.

关 键 词：核因子-E2相关因子2 血管 氧化应激 凋亡 

分 类 号：R743[医药卫生—神经病学与精神病学]