抑郁症患者脑血流速度和血黏度变化及相关性分析  

Change of cerebral blood flow velocity and blood viscosity and analyse related factors on patients with depressive disorder

作　　者：唐松林[1] 王艺明[2] 张福波[3] 

机构地区：[1]邵阳市第一人民医院神经内科,贵州邵阳422000 [2]贵阳医学院附属医院心理科,贵州贵阳550004 [3]沧州市中心医院神经内科,河北沧州061000

出　　处：《中国医药导报》2012年第33期61-64,共4页China Medical Herald

基　　金：贵州省贵阳市科学技术计划项目([2009]药科农合同字第3-008号)

摘　　要：目的探讨抑郁症患者脑血流速度和血黏度变化,并分析其相关性。方法收集56例符合中国精神障碍分类与诊断标准第3版（CCMD-3）的首发抑郁症患者,同时选取47名同性别、同年龄正常人作为对照组。所有入选者于清晨7∶00-8∶00空腹抽取肘部静脉全血,检查全血黏度;患者及对照者于当日下午15∶00-18∶00行经颅超声多普勒（transcranial Doppler sonography,TCD）检查各脑动脉的血流速度,并分析血黏度和血流速度两者之间的相关性。结果与对照组比较,抑郁症组全血黏度升高（P〈0.05）、双侧大脑前动脉、大脑中动脉及基底动脉的收缩峰流速、舒张末期流速、平均流速减慢、脉动指数降低（P〈0.05）。血流速度减慢的程度与病情轻重无关,血流速度的改变没有明显的偏侧化现象。抑郁症患者脑血流速度与血液黏度无相关性。结论抑郁症患者全血黏度升高,脑血流速度减慢。Objective To study the change of cerebral blood flow velocity and blood viscosity and to analyze related factors on patients with depressive disorder.Methods 56 patients（n = 56） with depression were selected and evaluated by the classification and diagnostic criteria of the Chinese Mental Disorders 3th dition（CCMD-3）,41 health people were selected as control group according to age,gender matching principle.The blood were taken from the subjects to check the content of hemorheological parameters in the early morning（7∶00-8∶00） and cerebral blood flow velocity was checked by transcranial Doppler sonography（TCD） in the afternoon（15∶00-18∶00）,and the correlation was analyzed between the two groups.Results Compered with control group,the whole blood viscosity（include high/middle/low shear rate） showed a increased data in the patients with depression,there was significant difference（P 0.05）.In the patients,bilateral decreased pulsatility index（PI） and blood flow velocities（Vs,Vm,Vd） were found in MCA,ACA and BA,the data of Vs,Vm,PI,ACA,MCA,BA had significant differences compered with control group（P 0.05）.However,there were not correlation with between blood flow velocities and severity of patients.There was not lateralization of cerebral blood flow velocity between two sides of the cerebral hemispheres,also there was no correlation between cerebral blood flow velocity and the blood viscosity.Conclusion The patients with depression have an increased blood viscosity and decreased blood flow velocities.

关 键 词：抑郁症 血液黏度 经颅超声多普勒 

分 类 号：R749.4[医药卫生—神经病学与精神病学]