垂体瘤卒中与流行病学相关分析  

An epidemiological analysis of pituitary apoplexy

作　　者：刘赫[1] 李溪江 黎庶[2] 蒋华[1] 曹翠萍[1] 张一奇[1] 刘国良[1] 

机构地区：[1]中国医科大学第一附属医院内分泌科,沈阳110001 [2]中国医科大学第一附属医院放射线科,沈阳110001 [3]本溪市金山医院内分泌科

出　　处：《中华内分泌代谢杂志》2012年第12期998-1000,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的分析垂体瘤卒中的流行特征，并探讨卒中所致的内分泌激素变化及特点。方法回顾性分析垂体瘤和垂体瘤卒中的临床、实验室、激素水平及内分泌功能检测、影像、术中及病理所见。结果（1）垂体瘤卒中发生率31．78％，年龄15～75（47．5±11．7）岁，女多于男；（2）伴糖尿病、冠心病、人T月经疗法、放疗、手术、溴隐亭可能与诱发卒中有关；（3）本资料无功能垂体瘤发生卒中率高；（4）本资料从卒中与垂体瘤间关系分为5型：卒中起病型、卒中加重型、卒中潜在型、卒中意外型和卒中术后型；（5）垂体瘤卒中易伴发低肌酐血症，高钠、氯血症，血嗜酸、嗜碱细胞减少症；（6）伴垂体激素缺乏高达61．61％，表现为单激素或多激素缺乏，其中GnH缺乏发生率最高；（7）98．10％采用手术治疗。结论垂体瘤卒中有特点的临床特征，应引起临床重视。Objective To analyze the epidemiological characteristics of pituitary apoplexy and investigate the changes and features of endocrine hormones caused by pituitary apoplexy. Methods A retrospective analysis of the clinical and laboratory data of pituitary tumor and pituitary apoplexy was carried out. Results （ 1 ） The incidence of pituitary apoplexy was 31.78%, patients were 15-75 （47.5 ± 11.7 ） year old, most patients were female. （2） Diabetes, coronary heart disease, menopausal hormone therapy, radiotherapy, surgery, and bromocriptine administration may be related to pituitary apoplexy. （ 3 ） There was high incidence of apoplexy in nonfunctioning adenoma. （4） According to the relationship between apoplexy and pituitary tumor, cases with pituitary apoplexy were divided into 5 types. （5） Pituitary apoplexy was associated with low serum creatinine, hypernatremia, hyperchloremia, hypoeosinophilia, and hypobasophilia. （6） 61. 61% of the patients had pituitary hormone deficiency, especially the GnH deficiency. （7）98. 10% of the patients were treated by surgery. Conclusion Pituitary apoplexy has its own clinical characteristics, and more attention should be paid in clinical practice.

关 键 词：垂体瘤卒中 分型 流行病学研究 

分 类 号：R736.4[医药卫生—肿瘤]