Distribution of Traditional Chinese Medicine patterns in 324 cases with hepatitis B-related acute-on-chronic liver failure:a prospective,cross-sectional survey  

作　　者：Xiaoyu Hu Yang Zhang Guo Chen Yibei Li Sen Zhong 

机构地区：[1]Department of Infectious Diseases,Affiliated Hospital of Chengdu University of Chinese Medicine [2]Department of Endocrinology,Affiliated Hospital of Chengdu University of Chinese Medicine

出　　处：《Journal of Traditional Chinese Medicine》2012年第4期538-544,共7页中医杂志（英文版）

基　　金：Supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China (No.2008ZX1005)

摘　　要：OBJECTIVE： To determine the distribution of Tradi- tional Chinese Medicine （TCM） patterns in hepatitis B-related acute-on-chronic liver failure （HB-ACLF） in different stages for guiding clinical prescriptions and treatments. METHODS： A prospective, cross-sectional survey method was used in this study. A total of 324 cases with HB-ACLF in China were involved. RESULTS： The general frequency of TCM patterns in HB-ACLF were as follows： Heat Toxin Stagnation Pattern （134/324, 41.36%）, Damp-heat Obstruction Pattern （66/324, 20.37% ）, Yong Qi Deficiency Pat- tern （52/324, 16.05%）, and Liver and Kidney Yin De- ficiency Pattern （26/324, 8.02%）. In the early stage of HB-ACLE there was a remarkably higher percent- age of excessive patterns than those in the middle and late stage. The incidence of Heat Toxin Stagna- tion reached 58.57% （82/140） in the early stage, while it was 33.96% （36/106） in the middle stage and 20.51% （16/78） in the late stage. In the early stage of HB-ACLF, excessive patterns, such as the Heat Toxin Stagnation Pattern, were more preva- lent than those in the middle and late stages （P〈a＇= 0.003）. However, in the late stage of HB-ACLE defi- cient patterns, such as the Yang Qi Deficiency Pat- tern, were more prevalent than those in the early and middle stages. The Yang Qi Deficiency Pattern had a higher rate of 41.03% （32/78） in the late stage compared with that of 20.75% （22/106） in the middle stage and 8.57% （12/140, P〈a＇ =0.003） in the early stage. The distribution of the other pat- terns was not significant between the three stages （P〉0.003）. CONCLUSIONS： There are four major patterns of HI3-ACLF, including the Heat Toxin Stagnation Pat- tern, the Damp-heat Obstruction Pattern, the Yang Qi Deficiency Pattern, and the Liver and Kidney Yin Deficiency Pattern. The Heat Toxin Stagnation and Yang Qi Deficiency Patterns are the representative patterns in the early and late stages of HB-ACLF. In the middle stage of HB-ACLF, the TCM pOBJECTIVE:To determine the distribution of Traditional Chinese Medicine(TCM) patterns in hepatitis B-related acute-on-chronic liver failure(HB-ACLF) in different stages for guiding clinical prescriptions and treatments.METHODS:A prospective,cross-sectional survey method was used in this study.A total of 324 cases with HB-ACLF in China were involved.RESULTS:The general frequency of TCM patterns in HB-ACLF were as follows:Heat Toxin Stagnation Pattern(134/324,41.36%),Damp-heat Obstruction Pattern(66/324,20.37%),Yang Qi Deficiency Pattern(52/324,16.05%),and Liver and Kidney Yin Deficiency Pattern(26/324,8.02%).In the early stage of HB-ACLF,there was a remarkably higher percentage of excessive patterns than those in the middle and late stage.The incidence of Heat Toxin Stagnation reached 58.57%(82/140) in the early stage,while it was 33.96%(36/106) in the middle stage and 20.51%(16/78) in the late stage.In the early stage of HB-ACLF,excessive patterns,such as the Heat Toxin Stagnation Pattern,were more prevalent than those in the middle and late stages(P<α ' = 0.003).However,in the late stage of HB-ACLF,deficient patterns,such as the Yang Qi Deficiency Pattern,were more prevalent than those in the early and middle stages.The Yang Qi Deficiency Pattern had a higher rate of 41.03%(32/78) in the late stage compared with that of 20.75%(22/106) in the middle stage and 8.57%(12/140,P<α ' =0.003) in the early stage.The distribution of the other patterns was not significant between the three stages(P>0.003).CONCLUSIONS:There are four major patterns of HB-ACLF,including the Heat Toxin Stagnation Pattern,the Damp-heat Obstruction Pattern,the Yang Qi Deficiency Pattern,and the Liver and Kidney Yin Deficiency Pattern.The Heat Toxin Stagnation and Yang Qi Deficiency Patterns are the representative patterns in the early and late stages of HB-ACLF.In the middle stage of HB-ACLF,the TCM patterns vary in a complicated manner,with no significant difference among the patterns.Treatment for HB-ACLF should vary with the different repre

关 键 词：Hepatitis B Liver failure  Acute Statisticaldistributions Traditional Chinese Medicine patterns 

分 类 号：R575.3[医药卫生—消化系统]