Development of a disease-specific health-related quality of life questionnaire for patients with post-stroke spasticity  

作　　者：Yanhong Zhang Baoyan Liu Zhishun Liu Yin Wang Hong Zhao Mingjie Zi Liping Wang Hong Liu Zhen Chen Ying Xie 

机构地区：[1]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences [2]China Academy of Chinese Medical Sciences [3]Guang'anmen Hospital,China Academy of Chinese Medical Sciences [4]Xiyuan Hospital,China Academy of Chinese Medical Sciences [5]Huguosi Hospital,Beijing University of Chinese Medicine [6]Xuanwu Hospital,Capital Medical University [7]Beijing Electric Power Hospital

出　　处：《Journal of Traditional Chinese Medicine》2012年第4期674-678,共5页中医杂志（英文版）

基　　金：Supported by China National Funds for Young Scientists (81001583);the National Fundamental Research and Development Grant(973 program,2006CB504601);the National Science and Technology Infrastructure Program (2004DEA71040)

摘　　要：OBJECTIVE： This study was designed to develop a disease-specific health-related quality of life （HR-QOL） measure for patients with post-stroke spasticity. METHODS; Based on responses from 20 patients with post-stroke spasticity and an extensive literature search, items potentially used to measure these patients＇ recovery status were identified and the Apoplexy Spastic-Paralysis Questionnaire （ASPQ） was formed. A sample of 106 patients was then tested twice using the ASPQ, the Self-rating Depression Scale （SDS） and the Stroke-specific Quality of Life （SS-QOL）. Clinicians also examined all the patients using the Ashworth Scale （AS）. Inter- nal reliability was assessed using Cronbach＇s coeffi- cient a, while construct validity was determined us- ing principal component analysis （PCA）. Empirical validity was evaluated between patients with de- pression and those without depression by single factor analysis. Sensitivity was examined by calcu- lating the Spearman correlation coefficient be- tween the changes in scores of the ASPQ, the AS and the SS-QOL. RESULTS： The ASPQ had adequate internal consis- tency reliability （a=0.874） and sensitivity, with sig- nificant correlations between the changes in scores of the AS, the SS-QOL and the ASPQ, with three do- mains. In a construct validity test, six factors were extracted; the overall variance explained by all fac- tors was 72.6%. For empirical validity, mean values of 19 items and 3 domains were all higher in the de- pressive patients than in the non-depressive pa- tients. CONCLUSION： The ASPQ is a reliable and valid self-rating scale for measuring the HR-QOL in pa- tients with post-stroke spasticity.OBJECTIVE:This study was designed to develop a disease-specific health-related quality of life(HR-QOL) measure for patients with post-stroke spasticity.METHODS:Based on responses from 20 patients with post-stroke spasticity and an extensive literature search,items potentially used to measure these patients' recovery status were identified and the Apoplexy Spastic-Paralysis Questionnaire(ASPQ) was formed.A sample of 106 patients was then tested twice using the ASPQ,the Self-rating Depression Scale(SDS) and the Stroke-specific Quality of Life(SS-QOL).Clinicians also examined all the patients using the Ashworth Scale(AS).Internal reliability was assessed using Cronbach's coefficient α,while construct validity was determined using principal component analysis(PCA).Empirical validity was evaluated between patients with depression and those without depression by single factor analysis.Sensitivity was examined by calculating the Spearman correlation coefficient between the changes in scores of the ASPQ,the AS and the SS-QOL.RESULTS:The ASPQ had adequate internal consistency reliability(α=0.874) and sensitivity,with significant correlations between the changes in scores of the AS,the SS-QOL and the ASPQ,with three domains.In a construct validity test,six factors were extracted;the overall variance explained by all factors was 72.6%.For empirical validity,mean values of 19 items and 3 domains were all higher in the depressive patients than in the non-depressive patients.CONCLUSION:The ASPQ is a reliable and valid self-rating scale for measuring the HR-QOL in patients with post-stroke spasticity.

关 键 词：Questionnaires Stroke HEMIPLEGIA Quality of life Sensitivity and specificity 

分 类 号：R743.3[医药卫生—神经病学与精神病学]