食管癌患者纤维蛋白原与D-二聚体检测的临床意义  

Clinical Significance of Fibrinogen and D-dimer Detection in Esophageal Cancer

作　　者：刘瑜[1] 林晓铭[1] 池闯[1] 程德志[1] 

机构地区：[1]温州医学院附属第一医院胸外科,325000

出　　处：《医学研究杂志》2012年第12期92-95,共4页Journal of Medical Research

基　　金：温州市科技局基金资助项目(Y20100052)

摘　　要：目的检测并研究食管癌患者血浆中纤维蛋白原(FIB)和D-二聚体(D-dimer,DD)的变化及其临床意义。方法对60例食管癌患者和8例健康人血浆中FIB和D-二聚体进行检测并同临床指标间进行统计学分析。结果食管癌组血浆中的FIB和D-二聚体水平明显高于正常对照组(P<0.01);同患者的淋巴结转移情况及P-TNM分期有关(P<0.05或P<0.01),而同性别及年龄不相关(P>0.05)。结论食管癌患者的FIB及D-二聚体高于正常,并同淋巴结转移及P-TNM分期相关且与患者的生存期呈明显的负相关。Objective To explore the clinical significance of fibrinogen and D - dimer detection in esophageal squamous cell canc- er. Methods The fibrinogen and D - dimer were detected in 60 esophageal cancer patients and 8 healthy adults, and the data were ana- lyzed with clinical indexes by SPSS. Results Levdel of fibrinogen and D - dimer in esophageal cancer patients were higher than that in healthy group（P 〈 0. 01 ）. There was relationship between fibrinogen and D -dimer levels and lymph node metastases and p -TNM stage （P 〈 0.05 or P 〈 0.01 ）. Otherwise, there was no relationship between fibrinogen and D -dimer levels and sex and age （P 〉 0.05 ）. Conclusion Compared with healthy group, significantly higher serum fibrinogen and D - dimer levels were detected in esophageal cancer patients. There was closely relationship between fibrinogen and D - dimer levels in esophageal cancer patients and lymph node metastases, p -TNM stage,and they were negatively correlated with lifetime,

关 键 词：食管癌 纤维蛋白原 D-二聚体 

分 类 号：R743.33[医药卫生—神经病学与精神病学]