胃癌患者辅助化疗后的生活质量及相关影响因素  

QOL of Gastric Cancer Patients Treated with Adjuvant Chemotherapy and Its Influencing Factors

作　　者：林铁素[1] 潘钰婷[1] 胡孙宽[1] 周琴[1] 金嵘[2] 

机构地区：[1]温州医学院附属第一医院消化内科,325000 [2]温州医学院附属第一医院科教科,325000

出　　处：《医学研究杂志》2012年第12期102-105,共4页Journal of Medical Research

基　　金：浙江省科技计划面上科研项目(2008C33066);温州市科技计划项目(H20060026)

摘　　要：目的探讨辅助化疗对胃癌患者生活质量的影响及相关影响因素。方法选取2007～2009年间温州医学院附属第一医院收治的胃癌患者。所有患者均在胃癌术后实施辅助化疗。采用EORTC QLQ-C30(V 3.0中文版)量表对患者化疗前及化疗后3、6、12个月的生活质量进行评估。结果随着化疗方案实施时间的推移,胃癌患者的生活质量、情绪功能、社会功能均有提高(分别为P<0.001,P=0.002和P=0.019),疲倦和经济困难指标有所改善(P=0.002和P=0.013),但XELOX和FOLFOX-4化疗方案间的生活质量无明显差异(P>0.05)。单因素分析表明,年龄、文化、收入、工作情况、参加集体活动、KPS评分、浸润深度、淋巴转移、脏器转移、肿瘤大体分型、病理类型、TNM分期、手术方式及合并器官切除等14个因素能进入多因素分析(P均<0.05)。多因素Logistic回归进入主效应模型的自变量是:淋巴转移、合并器官切除、KPS评分、手术方式及工作情况。结论联合化疗有助于提高患者的生活质量,淋巴转移、合并器官切除、KPS评分、手术方式及患者工作情况对胃癌化疗患者的生活质量影响显著。Objective To investigate the quality of life （QOL） and the main influencing factors in gastric cancer patients treated with adjuvant chemotherapy. Methods Gastric carcinoma patients in First Affiliated Hospital of Wenzhou Medical College from 2007 to 2009 completed the EORTC QLQ - C30（ V 3.0Chinese） scale at baseline and in the following - up intervals after adjuvant chemotherapy. Results Over the time of adjuvant chemotherapy, statistical improvement were seen in a number of domains and items, including global health/QL, emotional function, social function, tiredness and economic difficulties. There was no difference in QL between the XELOX group and FOLFOX - 4 group （P 〉 0.05）. Univariate analysis indicated that quality of life was related to age, educational background, income, working statement, attending group activity, KPS score, depth of tumor invasion, lymph node metastases, organ metastases,tumor differentiate grade, pathological category, TNM classification, operation method and combined multiple organ resection （ P 〈 0. 05）. Five factors including lymph node metastases, combined multiple organ resection, KPS score, operation method and working statement entered multivariate logistic regression equation. Conclusion Though XELOX has a similar QOL profile compared with FOL- FOX -4, the QOL of gastric cancer patients is improved after adjuvant chemotherapy. And factors of lymph node metastases, combined multiple organ resection, KPS score, operation method and working statement have obvious influence on the quality of life.

关 键 词：生活质量 辅助化疗 胃肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]