妊娠合并血液系统肿瘤20例临床分析  

Clinical Analysis of 20 Patients of Pregnancy Combined with Hematological Malignancy

作　　者：金珍琳[1] 梁彬[1] 

机构地区：[1]温州医学院附属第一医院,325000

出　　处：《医学研究杂志》2012年第12期162-165,共4页Journal of Medical Research

摘　　要：目的探讨妊娠合并血液系统肿瘤的处理及预后。方法回顾性分析妊娠合并血液系统肿瘤20例临床资料,其中急性白血病10例,慢性粒细胞白血病3例,恶性淋巴瘤1例,骨髓增生异常综合征6例。结果①治疗多采用联合化疗;②妊娠结局:孕早期治疗性流产3例,手术1例,中期引产5例,早产7例,足月分娩4例;③随访情况:失访1例,存活13例,死亡6例,中位随访时间45.4个月(5个月～11年);11例新生儿,目前均存活,中位随访时间54.5个月(3个月～11年),2例因病住院治疗,其余均正常。结论血液系统肿瘤对母儿均有不利影响,容易导致病理妊娠、早产儿、低体重出生儿、新生儿发育不良,甚至发生贫血,败血症等。只要及早诊断,并选择恰当的治疗方案,妊娠妇女的疗效通常比较满意。Objective To investigate the treatment and prognosis of hematological malignancy associated with pregnancy. Methods Clinical data of 20 patients in pregnancywith hematological malignancy,including 10 cases with acute leukemia（AL） , 3 cases with chronic myeloid leukemia（CML）,1 case with non- Hodgkin＇s lymphoma（NHL） and 6 cases with myelodysplastic syndrome（MDS） were ana- lyzed retrospectively. Results The most treatment method was applying combined chemotherapy. Pregnancy outcome was as the follow- ing： 3 patients were ended with therapeutic abortion and 1 patient was ended with operation in first trimester,5 were induced abortion in second trimester,7 premature delivery,4 term delivery. During the follow- up, 1 patient was lost, 13 patient survived,6 died. The median follow - up duration was 45.4months （ from 5 months to 11 years）. Of 11 newborn, all were alive, and the median follow - up duration was 54.5months （from 3 months to 11 years）. Two cases were hospitallized because of disease, and others all developed normally. Conclusion Hematological malignancy has adverse effect both on mother and infant, which tends to increasing the risk of pathological pregnancy, lead- ing to premature infant, low birth weight infant, newborn dysplasia, even anemia and septicemia. Pregnant women usually have favorable outcome through timely diagnosis and appropriate treatment.

关 键 词：妊娠 血液系统肿瘤 治疗 

分 类 号：R733[医药卫生—肿瘤]