脑内高表达microRNAs的时空效应及其在神经管缺陷中的可能作用  

Temporal and spatioal effects of enriched miRNAs in brain and possible role in neural tube defects

作　　者：白宝玲[1] 李会莉[1] 陈淑媛[1] 王晓蕾[1] 张勤[1] 赵慧智[1] 张霆[1] 

机构地区：[1]首都儿科研究所,北京100020

出　　处：《中国病理生理杂志》2012年第12期2291-2296,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.31071133);北京市科委科技新星资助项目(No.2010B045)

摘　　要：微小RNA（microRNA，miRNA）在生物体的发育生长、细胞增殖分化及凋亡、激素的分泌和肿瘤发生等领域中具有重要的调控功能。哺乳动物中枢神经系统的发育过程需要经历多个位点的神经管闭合，若神经管闭合失败或早闭，会导致神经管缺陷（neural tube defects，NTD）的发生，这是一种严重的、多因素的先天性复杂疾病，以往文献报道有多种miRNAs参与了NTD的发病机制。MicroRNAs （miRNAs） are known to play an important role in regulating the cell proliferation, dif- ferentiation and organogenesis. Abnormal expression of miRNAs is associated with increased risk for various diseases, such as neural tube defects （ NTD）, which is a severe developmental disease as the result of closing the neural tube incompletely or too early. The present review summarizes some enriched miRNAs in the brain of mammals and their spatial temporal fea- ture, and tries to elaborate the relationship between the aberrant expression of miRNAs and the pathogenesis of NTD.

关 键 词：微小RNA 神经管缺陷 哺乳动物 

分 类 号：R394.3[医药卫生—医学遗传学]