KAI-1基因在晚期肾癌中表达降低(英文)  

Decreased KAI-1 expression in advanced renal cell carcinoma

作　　者：孔宪国[1] 黄国华[1] 张元芳[2] 丁强[2] 王忠[2] 

机构地区：[1]上海铁道大学附属铁路医院泌尿外科,上海200072 [2]上海医科大学华山医院泌尿外科,上海200040

出　　处：《癌症》2000年第6期554-557,共4页Chinese Journal of Cancer

摘　　要：目的：探讨ＫＡＩ－１ｍＲＮＡ在肾细胞癌中的表达及与浸润转移的关系。方法：采用ＲＴ－ＰＣＲ方法检测３５例肾癌及癌周正常肾组织ＫＡＩ－１ｍＲＮＡ的表达。结果：肾癌组织中ＫＡＩ－１表达率明显低于癌周正常组织（Ｐ＜０.０５）；有肾周浸润或局部淋巴结转移的患者（Ⅲ、Ⅳ期）骨癌组织中ＫＡＩ－１表达明显低于Ⅰ、Ⅱ期患者（Ｐ＜０．０５）。结论：ＫＡＩ-１基因的低表达可能与肾细胞癌的进展有关。Objective: To investigate the expression of KAI-1 mRNA in renal cell carcinoma and the relationship with the metastasis. Method: RT-PCR was used to detect KAI-1 mRNA expression in specimens from 35 cases with renal cancer and adjacent normal kidney tissues. Results: KAI-1 expression rate in renal cancer was significantly lower than that in normal kidney tissues (P <0.05 ); tumors of patients with extrarenal invasion or regional lymph node metastasis (stage Ⅲ or Ⅳ) had significantly lower KAI-1 expression levels than tumors of patients with stage I or Ⅱ disease (P <0. 05) Conclusion: Decreased expression of the KAI-1 gene may he related to disease progression in patients with renal cancer.

关 键 词：肾肿瘤 KAI-1基因 肿瘤浸润 肿瘤转移 MRNA 

分 类 号：R737.11[医药卫生—肿瘤]