术中热化疗预防进展期胃癌腹腔种植转移的研究  

Clinical studies on prevention of post-operational intraperitoneal neoplasm seeding of advanced gastric cancer by surgery combined with intraperitoneal perfusion of hyperthermic mitomycin C

作　　者：谭春祈[1] 王心见[1] 徐亚琨[1] 江勃年[1] 曾福华[1] 

机构地区：[1]湖南省肿瘤医院,湖南长沙410006

出　　处：《实用肿瘤杂志》2000年第3期165-167,共3页Journal of Practical Oncology

摘　　要：:目的　评价手术联合 45℃丝裂霉素 (MMC)溶液腹腔灌注预防进展期胃癌腹腔种植转移的效果。方法　将 5 1例进展期胃癌随机分为手术联合 45℃ MMC腹腔灌注的实验组 2 2例及手术对照组 2 9例 ,术后随诊 3年 ,比较两组的生存率及腹腔种植率。结果　实验组 1、2、3年生存率分别为 94.9%、83.7%及 83.7%。对照组为 86 %、5 3.6 %与 5 3.6 % ,生存率前者高于后者 (P=0 .0 31) ,腹腔种植率实验组为 0 % ,对照组为 2 2 .2 % ,(P=0 .0 41)。结论　手术联合 45℃ MMC腹腔灌注有希望预防进展期胃癌术后腹腔种植 ,提高近期生存率。Objective To evaluate the efficacy of surgery combined with hyperthermic mitomycin C (MMC) as prophylaxis against intraperitoneal tumor seeding of advanced gastric cancer.Methods Fifteen one patients of advanced gastric cancer were randomly divided into two groups∶group A (n=22) was treated with surgery combined with intraperitoneal perfusion of 45℃ hyperthermic MMC (IPHM),and group B (n=29) with surgery only.Both groups were followed up for 3 years after operation,and the one year、two year、three year survival rates as well as peritoneal tumor seeding rates were compared.Results The 22 patients given IPHM lived longer than the 29 patients with surgery only ( P =0.031),with 1 year、2 year、3 year survival rates of 94.9%、83.7% and 83.7% in the former group and 86.0%、53.6%、53.6% in the latter.The peritoneal tumor seeding rate of IPHM group was 0% versus 22% in the control group ( P =0.041).Conclusions The therapy of surgery combines with IPHM offers the promise of prolonged survival for patients with advanced gastric cancer and may effectively prevent post operational peritoneal tumor seeding of advanced gastric cancer.

关 键 词：胃肿瘤 肿瘤转移 外科手术 热化疗 

分 类 号：R735.205[医药卫生—肿瘤] R73－37[医药卫生—临床医学]