原发性胃恶性淋巴瘤临床与病理研究  

Study of Clinic and Pathology on Primary Gastric Malignant Lymphoma

作　　者：陶金[1] 林颖[1] 李建忠[1] 陈小良[1] 田虹[1] 郑丰平[1] 吴斌[1] 

机构地区：[1]中山大学附属第三医院消化内科,广东广州510630

出　　处：《中山大学学报（医学科学版）》2012年第6期803-807,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(30971357);广东省科技计划项目(2009B060300001)

摘　　要：【目的】分析原发性胃恶性淋巴瘤(PGML)的临床与病理学特点,为临床诊断及治疗提供参考。【方法】对2006年1月至2012年6月我院收治的35例经病理确诊的PGML患者的临床资料与病理学特点进行分析。【结果】PGML发病以50岁以上人群为主,占65.7%,男女比例为1.69∶1。其临床表现缺乏特异性,胃镜和CT表现与胃癌等其他胃部疾病较难鉴别,内镜下多部位深活检可提高诊断阳性率,手术联合化疗治疗可获较满意疗效。【结论】原发性胃恶性淋巴瘤多属B细胞来源,胃镜检查及活检是术前最有诊断价值的方法,临床治疗方案的选择应根据临床分期、病理类型及病人情况进行规范化处理。[Objective ] To analyze the clinical characteristics, pathological features and treatment of primary gastric malignant lymphoma, and to offer a reference on clinical diagnosis and management. [ Methods ] The clinical and endoscopic features were analyzed, and pathological data were investigated in 35 patients who were hospitalized in our hospital and diagnosed by histopathology as PGML from January 2006 to June 2012. [ Resuhs] There was a higher morbidity for the crowd over 50-years-old, amounting to 65.7%. The ratio of males and females was 1.69 ： 1. PGML was lack of specified clinical presentation. The characteristic manifestations of gastroscopy and computed tomography were difficult to identify malignant tumor. Multiple and deep biopsies in gastroscopy can significantly raise the rate of diagnosis for PGML. Surgical resection combined with postoperative chemotherapy was an effective therapy. [ Conclusions ] For PGML, B-cell lymphomas is significant higher than other types, and a gastroscopy with biopsies is the best diagnostic method. The treatment should be considered with the clinical stage, pathologic type, and the patient＇s tolerance.

关 键 词：原发性胃恶性淋巴瘤 胃镜检查 病理分型 

分 类 号：R735.2[医药卫生—肿瘤]