P^(53)基因产物在肾盂癌及癌旁组织表达的意义  

P^(53)protein expression in pelvic carcinoma and pericarcinous tissue

作　　者：牛天力[1] 俞天麟[1] 张绍增[1] 邢传平[1] 刘华福[1] 

机构地区：[1]兰州军区兰州总医院,甘肃兰州730050

出　　处：《西北国防医学杂志》2000年第2期99-100,共2页Medical Journal of National Defending Forces in Northwest China

基　　金：甘肃省自然科学基金资助项目!(ZR-94-092)

摘　　要：目的 :探讨P53 基因产物在肾盂癌及癌旁组织表达的意义。方法 :用免疫组织化学方法对 36例肾盂癌及癌旁组织研究 ,并和 7例正常肾盂组织进行对照。结果 :P53 蛋白在肾盂癌中阳性率为 41.7% ,癌旁组织阳性率为 8.3% ;在肾盂癌的病理分期和分级中 ,P53 蛋白的表达强度随分期、分级升高而增强。结论 :P53Objective:To investigate the significance of P53 protein expression in pelvic carcinoma and pericarcinous tissue.Methods:The samples from 36 pelvic carcinomas and their pericarcinous tissues were detected by immunohistochemical technique,and 7 normal pelvic tissues were as controls.Results:The positive ratios of P 53 protein expression were 41.7% and 8.3% in carcinomas and pericarcinous tissues respectively.P 53 protein was over expression with the promoting pathologic grade and stage.Conclusion:It might be unfavourable prognosis when positive expression of P53 shows in pelvic carcinoma and pericarcinous tissue.

关 键 词：肾盂癌 癌旁组织 P^53蛋白 基因表达 

分 类 号：R737.11[医药卫生—肿瘤]