原发性气管腺样囊性癌15例临床病理分析  

Clinicopathologic features of 15 primary tracheal adenoid cystic carcinoma cases

作　　者：孙晓腾 何妙侠[2] 王洋[2] 陶立阳[2] 蒋慧[2] 朱炎[2] 

机构地区：[1]乳山市人民医院病理科,山东乳山264500 [2]第二军医大学附属长海医院病理科,上海200433

出　　处：《中华肿瘤防治杂志》2012年第18期1420-1423,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨15例原发性气管腺样囊性癌患者临床病理学特征,诊断与鉴别诊断以及治疗原则。方法:回顾性分析上海长海医院近2年诊治的15例原发性气管腺样囊性癌患者临床病理资料。结果:原发性气管腺样囊性癌多以呼吸道症状就诊,早期容易误诊。显微镜下:肿瘤组织由腺管状、筛孔状和实性团巢状结构构成,管腔内可见过碘酸雪夫反应(PAS)阳性的黏液样物质。免疫组化显示,肿瘤细胞表达腺上皮和肌上皮标记。结论:原发性气管腺样囊性癌是一种少见的低度恶性肿瘤,临床症状无特异性,行支气管镜检查以及病理活检利于早期诊断,治疗以手术切除及局部放疗较好。OBJECTIVE： To explore the clinicopathologic features and differential diagnosis of primary tracheal ade- noid cystic carcinoma （ACC）. METHODS： Fifteen cases of tracheal ACC were investigated clinico-pathologically and im- munohistochemically in 2 years. RESULTS： All cases had cough, stridor or progressive inspiratory dyspnea, which were easy to be misdiagnosed. Microscopically, the tumor showed invasive growth pattern underneath the mucous membrane and forming typical eribriform and tubal structures. Myxoid mass was seen with PAS positive in the lumens. Immunohisto- chemically, glandular epithelial and myoepithelial marks were both expressed in the tumor tissue. CONCLUSIONS： Primary tracheal ACC is a rare tracheal tumor,most of which is low grade tumor with nonspecified clinical symptoms. Bronchosco- py and biopsy are useful for early diagnosis,and the best treatment is excision combined with radiotherapy for primary tra- cheal ACC.

关 键 词：原发性气管肿瘤 腺样囊性癌 临床病理特征 

分 类 号：R734.1[医药卫生—肿瘤]