乳头型颅咽管瘤19例临床病理分析  

Clinicopathological features of papillary craniopharyngioma:a report of 19 cases

作　　者：韩春[1] 张福林[1] 唐峰[1] 毕海霞[1] 胡杰[2] 徐伟[2] 黄锋平[2] 

机构地区：[1]复旦大学附属华山医院静安分院(上海市静安区中心医院)病理科,上海200040 [2]复旦大学附属华山医院神经外科,上海200040

出　　处：《临床与实验病理学杂志》2012年第12期1314-1316,1321,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨乳头型颅咽管瘤的临床病理特征、诊断与鉴别诊断。方法回顾性分析19例乳头型颅咽管瘤的临床特征、病理学形态和免疫表型,并复习相关文献。结果 19例患者中男性11例,女性8例,年龄25～66岁,平均44岁。镜下见肿瘤组织由复层上皮细胞围绕纤维血管形成乳头状结构。其中1例包括两种类型,部分肿瘤为造釉细胞型伴有胆固醇裂隙,小部分为乳头型,1例伴有少量纤毛柱状上皮和杯状细胞;1例伴有鳞状上皮分化。结论颅咽管瘤的乳头型较造釉细胞型少见,影像学易与垂体腺瘤相混淆,明确诊断依赖病理组织学及免疫表型。Purpose To investigate the clinicopathological features, diagnosis, differential diagnosis of papillary craniopha^cngioma. Methods The clinical features, histopathological changes and immunohistochemieal findings were analyzed in 19 cases of papillary craniopharyngioma, with review of the related literature. Results Among 19 cases of papillary craniopharyngioma, the male to female ratio was ll ： 8. The patient＇ s age were 25 N 66 years （ median 44 years）. Tumor tissue had papillary structures covered with more layers of epitheial ceils around a fibrovascular core under the microscope. One case included two types, some of adamantinomatous area associated with cholesterol clefts, a small portion of papillary pattern, one case with a small amount of ciliated columnar epithelium and goblet cells, and one case with well-differentiated squamous epithelium. Conclusion Papillary craniopharyngioma is less than ada- mantinomatous type, and it is extremely difficult to distinguish radiologically from pituitary adenoma. The diagnosis mainly relies on histopatholo~ and immunohistochemistrv.

关 键 词：颅咽管瘤 乳头型 病理学 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]