人脑胶质瘤PTEN和Survivin及HIF-1α蛋白表达临床意义的探讨  

Significance and expressions of PTEN,Survivin and HIF-1α in gliomas

作　　者：姜京超 吕玉玲[1] 纪宇明[1] 姜慧峰[1] 彭龙锋[1] 王树兴[1] 李学芝[1] 

机构地区：[1]烟台市莱阳中心医院神经外科,山东莱阳265200

出　　处：《中华肿瘤防治杂志》2012年第20期1532-1534,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:研究PTEN和Survivin及HIF-1α蛋白在不同病理分级的胶质瘤中的表达特征及意义。方法:采用免疫组织化学法检测68例脑胶质瘤和10名正常人脑组织标本中PTEN、Survivin和HIF-1α蛋白表达。结果:PTEN蛋白在Ⅰ～Ⅱ级胶质瘤中阳性率为76.47%(26/34),高于Ⅲ～Ⅳ级阳性率为32.35%(11/34),P=0.016;Survivin和HIF-1α蛋白在Ⅰ～Ⅱ级胶质瘤中阳性率为55.88%(19/34)和50.00%(17/34),低于其在Ⅲ～Ⅳ级胶质瘤中阳性表达率为88.24%(30/34)和85.29%(29/34),χ2值分别为8.838和9.676,P均<0.05。PTEN蛋白与Survivin和HIF-1α蛋白的表达均呈负相关,r值分别为-0.504和-0.317,P值分别为0.000和0.008,Survivin蛋白与HIF-1α蛋白的表达呈正相关性,r=0.550,P=0.000。结论:PTEN、Survivin和HIF-1α蛋白表达状态与胶质瘤的分化程度及进展密切相关,联合检测PTEN、Survivin和HIF-1α蛋白有助于判断肿瘤的侵袭性及预后。OBJECTIVE： To investigate the significance and expression profile of PTEN,Survivin and HIF-lα in gli omas with various histopathologic grades. METHODS： The immunostainings for PTEN,Survivin and H IF-lα were per formed in 68 cases of gliomas and 10 cases of normal brain tissues. RESULTS： The positive staining rate of PTEN in glio mas of grade Ⅰ and Ⅱ （76.47 %, 26/34） was higher than those in grade Ⅲ and 1V （32.35 %, 11/34, P = 0.016）. The posi- tive slaining rate of Survivin and HIF-lα in gliomas of grade Ⅰ and Ⅱ was lower than those in the grade Ⅲ and IV [88. 24%（30/34） ,85.29%（29/34） ,X2 values were 8. 838 and 9. 676,P〈0. 053. The expression of PTEN was negatively correlated with the one of Survivin and HIF-la（r were -0. 504 and -0. 317,respectively,and P were 0. 000 and 0. 008）. The expression of HIF-lα was positively correlated with expression of Survivin （r = 0. 550, P = 0. 000）. CONCLUSION： The expression profiles of PTEN, Survivin and HIF-lα in gliomas are closely correlated with tumor differentiation and progression,and the combined detection of PTEN,Survivin and HIF-lα proteins may be helpful to assess the tumor ag gressivon and prognosis.

关 键 词：脑肿瘤 病理学 神经胶质瘤 免疫组织化学 肿瘤蛋白类 

分 类 号：R739.4[医药卫生—肿瘤]