化疗联合介入栓塞术治疗结直肠癌肝转移疗效分析  

Efficacy of chemotherapy and interventional embolization for the treatment of colorectal cancer with liver metastases

作　　者：林晓萍[1] 张武[1] 陈文俊[1] 虞希祥[1] 王春妹[1] 

机构地区：[1]浙江省瑞安市人民医院高压氧治疗科,浙江瑞安325200

出　　处：《中国现代医生》2012年第34期142-144,共3页China Modern Doctor

基　　金：浙江省温州市第三期科技计划项目(Y20110201)

摘　　要：目的探讨化疗联合介入栓塞术治疗结直肠癌肝转移的疗效。方法选择2009年1月～2012年1月在我院住院治疗的结直肠癌肝转移患者64例为研究对象,随机分为实验组(化疗联合介入栓塞术治疗)和对照组(化疗)各32例,比较两组的临床疗效。结果实验组有效率达65.6%,明显高于对照组(46.9%)(P<0.05)。实验组临床获益率达81.25%(26/32),对照组达68.75%(22/32),实验组临床获益明显高于对照组(P<0.05)。实验组的无进展生存期(PFS)为9.7个月,对照组为8.1个月。两组在骨髓抑制及胃肠道反应、肝肾功能方面比较未见明显差异,但实验组周围神经毒性Ⅲ+Ⅳ级的发生率明显低于对照组,而发热Ⅱ+Ⅳ级的发生率明显高于对照组(P<0.05)。结论化疗联合介入栓塞术治疗结直肠癌肝转移疗效确切,可以有效提高生活质量,延长生存期,毒副反应轻,值得推广和应用。Objective To explore the chemotherapy combined interventional embolization for the treatment of colorectal cancer liver metastases efficacy. Methods From January 2009 to 2012 in January,selected our hospital the treatment of colorectal liver metastases 64 patients for the study, were randomly divided into experimental group （chemotherapy and em- bolization therapy） and control group （chemotherapy） each 32 cases, the clinical efficacy of the two groups were compared. Results There were efficiency comparison： the experimental group 65.6%, significantly higher than that in the control group （46.9%）（P 〈 0.05） clinical benefit rate compared with the experimental group was 81.25% （26/32）, the control group amount- ed to 68.75% （22/32）, the clinical benefit of the experimental group was significantly higher than that in the control group （P 〈 0.05）. Follow-up to March 2012, Experimental group, progression-free survival （PFS） was 9.7 months in the control group PFS was 8.1 months.The two groups in the incidence of class Ⅱ ＋Ⅳ myelosuppression and gastrointestinalreactions, liver and kidney function showed no significant difference, but around the experimental group neurotoxicity Ⅲ＋Ⅳ level incidence was significantly lower than the control group, and the fever obvious higher than those in the control group （P 〈 0.05）. Conclusion Chemotherapy and interventional embolization for the treatment of colorectal liver metastases is effective and can effectively improve the quality of life and prolong survival, lighten toxicity, worthy of promotion and application.

关 键 词：结直肠癌 肝转移 化疗 介入栓塞术 

分 类 号：R735.3[医药卫生—肿瘤]