N-(4-胍基丁基)丁香酰胺对家兔血小板聚集性的影响  

Inhibitory effect of syringoylagmatine on platelet aggregation in rabbit

作　　者：许勤龙[1] 周鹏[1] 李家明[1] 张恩立[1] 胡敏华[1] 

机构地区：[1]安徽中医学院药学院安徽现代中药重点实验室,安徽合肥230031

出　　处：《安徽医药》2012年第12期1762-1764,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省高校自然基金重点项目(NoKJ2010A206)

摘　　要：目的考察N-(4胍基丁基)丁香酰胺对家兔体外血小板聚集的影响。方法以盐酸益母草碱为阳性对照,以二磷酸腺苷(Adenosine Diphosphate,ADP),花生四烯酸(Arachidonic Acid,AA),胶原(Collagen,COL)为诱导剂诱导家兔体外血小板聚集,采用Born氏比浊法,利用血小板聚集仪测定5 min血小板最大聚集率,观察不同浓度的N-(4胍基丁基)丁香酰胺对家兔体外血小板聚集的影响。结果不同浓度N-(4胍基丁基)丁香酰胺对ADP、AA、COL诱导的家兔体外血小板聚集均有一定抑制作用。结论 N-(4胍基丁基)丁香酰胺具有一定的体外抗血小板聚集的作用。Objective To investigate the inhibitory effect of syringoylagmatine on rabbit platelet aggregation in vitro.Methods We measured the maximum of platelet aggregation（expressed in percentage） within 5 minutes which was induced by ADP,COL and AA according to the born turbid imetric method with a platelet aggregometer.Results Each group of syringoylagmatine can inhibit the platelet aggregation induced by ADP,AA and COL in vitro.Some groups of syringoylagmatine were more active than leonurine.Conclusion Syringoylagmatine can inhibit platelet aggregation induced by ADP,COL and AA in vitro to some extent.

关 键 词：N-(4胍基丁基)丁香酰胺 血小板聚集 家兔 

分 类 号：R965[医药卫生—药理学]