恶性纤维组织细胞瘤的免疫组织化学研究  

IMMUNOHISTOCHEMICAL STUDY OF MALIGNANT FIBROUS HISTIOCYTOMA

作　　者：陶瑜[1] 吉重敏 任超玲 熊敏[1] 吴惠茜[1] 侯婉英 梁政奎 

机构地区：[1]中山医科大学病理学教研室,广州510089

出　　处：《癌症》1991年第2期107-109,共3页Chinese Journal of Cancer

摘　　要：本文对23例恶性纤维组织细胞瘤((MFH)及19例其他软组织肿瘤的免疫组化研究表明,AACT,AAT阳性率最高,是肿瘤性组织细胞的良好标志物,对MFH有一定诊断价值。Lys不是恶性组织细胞的良好标志物。Des的表达提示部分肿瘤细胞向肌纤维母细胞分化,Vim的表达则提示向纤维母细胞分化。所以,我们的研究结果表明MFH可能来自未分化间叶细胞,并在不同情况下向组织细胞、纤维母细胞和肌纤维母细胞等不同方向分化,而表现出复杂的组织学形态。23 cases of malignant fibrous histiocytoma (MFH) and 19 cases ofother soft tissue tumors were studied by immunohistochemical technique. The results showed that the highest positivity of AACT, AAT in MFH indicating these may be used as markers of malignant histiocytes and may give diagnostic aid. 'Lys' is a poor marker of malignant histiocytes, while 'Des' expression in some tumor cells was proposed to be a marker for differentiating into myofibroblasts, and 'Vim' expression indicated differentiating into fibroblasts. Our results showed that MFH may be derived from undifferentiated mesen-chymal cells which developed into histiocytes, fibroblasts of myofibroblasts, thus exhibited a mixed histological feature.

关 键 词：软组织肿瘤 免疫组织化学 MFH 

分 类 号：R738.603[医药卫生—肿瘤]