MicroRNA在炎症性肠病中的研究进展  

Advances in Study of MicroRNA in Inflammatory Bowel Disease

作　　者：徐睿玲[1] 刘冰熔[1] 

机构地区：[1]哈尔滨医科大学第二附属医院消化内科,哈尔滨150086

出　　处：《医学综述》2012年第23期3944-3947,共4页Medical Recapitulate

摘　　要：炎性肠病(IBD)是遗传易感宿主对异常的环境因素作出免疫反应的结果。小分子RNA(MicroRNA,miRNA)是一类长约22个核苷酸、内源性、高度保守的非编码小分子RNA,调控人体多种生理过程。目前发现,miRNA在IBD中表达异常,这可能有助于今后明确IBD的发病机制,并且在疾病的诊断、靶向治疗中有重要意义。Inflammatory bowel disease（IBD）is the consequence of an abnormal immune response to environmental factors in genetically susceptible hosts.MicroRNA is a class of noncoding small RNA molecules with the features of about 22 nucleotides,endogenous,and highly conservative,which can regulate a variety of human physiological processes.Recently,unique microRNA expression profiles have been described in IBD,which may help to clarify the pathogenesis of IBD,and have a great significance in diagnosis and targeted therapy of IBD in the future.

关 键 词：炎症性肠病 小分子RNA 炎症 

分 类 号：R574[医药卫生—消化系统]