老年局灶进展性胃癌手术前后多西紫杉醇联合辅助化疗结局分析  

Outcome of Docetaxel Combination Adjuvant Chemotherapy before and after Operation among Older Patients with Focal Progressing Stomach Cancer

作　　者：郭凤生 

机构地区：[1]河南省鹤壁市京立肿瘤医院外科,河南鹤壁458030

出　　处：《医学综述》2012年第23期4068-4070,共3页Medical Recapitulate

摘　　要：目的比较局灶进展性胃癌分别于手术前后采用多西紫杉醇为基础辅助化疗的结局。方法选择70例已确诊的局灶进展性胃癌患者,分为手术前组和手术后组,分别于手术前或手术后接受多西紫杉醇+顺铂+氟尿嘧啶(TCF)4个疗程的治疗。结果共计化疗189个TCF周期,手术前组118个,手术后组71个。手术前组完成4个周期26例(74%),3个周期1例,2个周期3例,1个周期5例;手术后组完成4个周期12例(34%),3个周期2例,2个周期5例,1个周期16例。发生严重不良反应事件手术前组13例次,手术后组19例次,两组相比有统计学意义(χ2=6.533,P<0.05)。手术前化疗者手术切除32例(94%)。结论局灶进展性胃癌多西紫杉醇基础辅助化疗后手术较手术后化疗安全,且化疗不良反应少。Objective To compare the outcome of docetaxel combination adjuvant chemotherapy of before and after operation among older patients with focal progressing stomach cancer.Methods 70 patients with focal progressing stomach cancer were divided into preoperation group and postoperation group,the patients of which received docetaxel,cisplatin and 5-fluorouracil（TCF）for four courses of treatments before operation or after operation,respectively.Results 189 TCF cycles were completed,including 118 in preoperation group and 71 in postoperation group.26 patients completed 4 cycles in preoperation group and 12 patients in postoperation group,1 patient completed 3 cycles in preoperation group and 2 in postoperation group,3 patients completed 2 cycles in preoperation group and 5 in postoperation group,5 patients in preoperation group completed 1 cycle and 16 in postoperation group,respectively.Serious adverse events emerged 13 times in preoperation group and 19 in after operation group（χ2=6.533,P0.05）.Surgical resections was 32 patients in preoperation group（94%）.Conclusion It is safer and of less adverse reactions to carry out basic docetaxel adjuvant chemotherapy before operation.

关 键 词：胃癌 多西紫杉醇 辅助化疗 腹腔镜 手术 

分 类 号：R735.2[医药卫生—肿瘤]