染色体9p21基因单核苷酸多态性与新疆维吾尔族人群冠心病的关系  

Association of SNPs on chromosome 9p21 with coronary heart disease in Xinjiang Uygur nationality

作　　者：马建军[1] 焦昌安[2] 陈刚[1] 高学忠[1] 刘刚[1] 石文蕾[2] 张煜[2] 邱朝晖[2] 王姣锋[3] 缪应新[4] 郭新贵[2] 

机构地区：[1]新疆阿克苏地区第一人民医院心内科,新疆阿克苏843000 [2]复旦大学华东医院心内科,上海200040 [3]复旦大学华东医院科教科,上海200040 [4]复旦大学华东医院检验科,上海200040

出　　处：《新疆医科大学学报》2012年第12期1638-1642,共5页Journal of Xinjiang Medical University

基　　金：上海市自然科学基金(09ZR1420200);上海市卫生局科研课题(2010122)

摘　　要：目的探讨染色体9p21基因单核苷酸多态性(single nucleotide polymorphism,SNP)与新疆维吾尔族人群冠心病(coronary heart disease,CHD)的关系。方法选择172例冠状动脉造影证实的CHD患者(冠心病组)和147例对照组作为研究对象,应用LDR-PCR技术对rs1333049位点进行SNP分型及分析。结果冠心病组和对照组rs1333049CC基因型频率分别为39.0%和20.4%,C等位基因频率分别为59.9%和48.6%;两组比较差异有统计学意义(P<0.05)。调整相关因素后,多因素Logistic回归分析结果提示rs1333049CC基因型仍是CHD的危险基因型,OR值为2.40,95%CI(1.25～4.61)。结论 rs1333049多态性与维吾尔族人群CHD易感性相关。Objective To investi some 9p21 with coronary heart gate the association of single nucleotide polymorphism （SNP） on chromo disease in Xinjiang Uygur nationality. Methods One hundred and seventy two patients were involved for CHD group and 147 subjects for control group according to the results of coronary angiograph. Rs1333049 was genotyped by LDR PCR technique. Results The CC genotype fre quencies of rs1333049 in CHD group and in control group were 39.0% and 20.4%, respectively.lele C frequencies were 59.9% and 48.6%, respectively. The differences between two groups was statistically significant （P d0.05）. Multi-logistic regression analyses showed that CC genotype of rs1333049 was still the risk factor of CHD after adjustment of related factors （OR 2.40,95% CI 1.25--4.61）. Conclusion risk This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with for CHD in Xinjiang Uygur nationality.

关 键 词：冠心病 9p21 单核苷酸多态性 

分 类 号：R394.2[医药卫生—医学遗传学]