肿瘤标志物联合检测判断大肠癌复发转移的研究进展  

New progression in diagnosing the recurrence and metastasis of colo- rectal cancer by combining detection of tumor markers

作　　者：胡送娇[1] 殷佩浩[1] 李琦[1] 

机构地区：[1]上海中医药大学附属普陀医院,上海中医药大学中西医结合肿瘤介入研究所,上海200062

出　　处：《国际外科学杂志》2012年第12期843-845,共3页International Journal of Surgery

基　　金：国家自然科学基金青年基金（No.81001594）;上海市卫生局中医处资助项目（No.2010QL050B）;上海市普陀区重大项目（No.2011PTZD01）;市科委引导项目（No.11411963100）

摘　　要：大肠癌的转移是一个多因素多基因共同作用的结果，术后复发转移是其预后不良的重要原因。由于肿瘤发展是一个动态的过程，不同阶段肿瘤标志物的浓度随肿瘤的发展而变化，而且目前尚未发现任何一种肿瘤标志物为某一类型大肠癌所特有，因此单项肿瘤标志物的敏感性和特异性均不理想，较佳的肿瘤标志物组合可以提高临床早期诊断率，具有单项检测不具有的优势。采用多种标志物联合检测，有利于提高诊断的阳性率。Extensive researches suggest that the metastasis of colorectal cancer involves multiple factors and genes. Recurrence and metastasis after surgery are the important reasons for poor prognosis of these patients with colorecta] cancer. Tumorigenesis is a dynamic process. The levels of tumor markers are changed in different stages. It has not yet been found any kind of tumor markers specific for a certain type of colorectal cancer. The sensitivity and specificity of diagnoising colorectal cancer by detecting an individual tumor marker are not ideal. The better combination of tumor markers has its advantages, can improve the early diagnostic rate. Combining detection of tumor markers will improve the diagnostic yield.

关 键 词：大肠肿瘤 肿瘤转移 肿瘤标志物 联合检测 

分 类 号：R735.34[医药卫生—肿瘤]