胃肠腺癌增殖细胞核抗原表达及意义  

Proliferating Cell Neuclear Antigen(PCNA) Expression in Gastric and Colorectal Adenocarcinoma

作　　者：彭敦发 齐琼 

出　　处：《皖南医学院学报》2000年第2期87-88,97,共3页Journal of Wannan Medical College

摘　　要：应用免疫组化方法检测了53例胃癌及55例大肠癌增殖细胞核抗原（PCNA）的表达，并探讨了PCNA分级与临床病理因素间的关系。结果显示正常肠腺体PCNA阳性细胞限于粘膜的下1／3区，在癌旁移行粘膜，PCNA阳性细胞数量增多，且阳性细胞带上移。而胃肠腺癌中PCNA阳性细胞分布呈异质性，在肿瘤浸润前沿一般都较强。PCNA表达与胃癌的浸润范围有关，PCNA分级高者，侵及浆膜及浆膜外的比例明显高于PCNA分级低者（P＜0．05），在大肠癌中也显示类似趋势，但P＞0．05。表明免疫组织化学方法检测PCNA是一种较简便的检测肿瘤细胞增殖活性的方法，其结果可能有助于临床对肿瘤进展的判断。Proliferating cell nuclear antigens(PCNA) in 53 cases of gattric adenocarcionma and 55 cases of colorectal adenocarcinoma in paraffin embedded tissues were detected immunohistochemically, and corelated PCNA grades with clinicopathological features. PCNA peitive cells were located in lower 1/3 zone in normal gastric and colorectal mu cosas, while in most samples of paracancerous mucosas, PCNA positive cells were found even in the upper 1/3 zone and abnormally PCNA grades were higher. In carcinomas, PCNA positive cells scattered in the tissues, but stronger in the infiltrating margins. And high PCNA grades related to the infiltrating depth of gastric cancer(P<0.05). It is suggested that the detection of PCNA by immunohistochemistry is a simple method of determining tumor cell proliferat ing activity, and may be useful in evaluating tumor progression.

关 键 词：胃肿瘤 大肠肿瘤 腺癌 增殖细胞核抗原 

分 类 号：R735.202[医药卫生—肿瘤] R735.340.2[医药卫生—临床医学]