阿托伐他汀对血脂正常急性脑梗死患者血清肿瘤坏死因子α和白细胞介素6的影响  

Influence of atorvastatin on serum tumor necrosis factor-α and interleukin-6 in patients of acute ischemic stroke with normal lipidemia

作　　者：王小平[1] 马金梁[2] 

机构地区：[1]孝感市中心医院神经内科,湖北孝感432000 [2]荆州市第一人民医院骨科,湖北荆州434000

出　　处：《临床荟萃》2013年第1期33-34,37,共3页Clinical Focus

摘　　要：目的观察阿托伐他汀对血脂正常急性脑梗死患者血清肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)的影响。方法将62例血脂水平正常急性脑梗死患者随机分为对照组(31例)与观察组(31例),对照组给予常规治疗,观察组在常规治疗基础上加服阿托伐他汀20mg/d治疗12周。分别于治疗前后检测患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及血清TNF-α和IL-6水平,并进行神经功能缺损评分(NIHSS)。结果治疗后,观察组TC、TG、LDL-C、NIHSS评分及血清TNF-α和IL-6水平均较对照组明显降低(P<0.05),分别为TC(4.21±0.88)mmol/L vs(4.69±0.93)mmol/L,TG(1.12±0.46)mmol/L vs(1.26±0.42)mmol/L,LDL-C(2.23±0.55)mmol/L vs(2.82±0.59)mmol/L,NIHSS评分(10.56±3.61)分vs(15.35±3.92)分,TNF-α(9.95±3.68)μg/L vs(15.42±3.79)μg/L,IL-6(10.34±2.81)μg/L vs(14.27±3.12)μg/L,而HDL-C较对照组显著升高(1.29±0.38)mmol/L vs(1.11±0.34)mmol/L(P<0.05)。结论阿托伐他汀有助于血脂水平正常急性脑梗死患者脑梗死后神经功能的恢复,其机制可能与降低患者血清TNF-α和IL-6水平、抑制炎症反应有关。Objective To observe the influence of atorvastatin on serum tumor necrosis factor-a（TNF-α） and interleukin-6（IL-6） in patients of acute ischemic stroke with normal lipidemia. Methods Sixty-two cases of patients of acute ischemic stroke with normal lipidemia were randomly divided into the treatment group（ n = 31） and the control group（ n = 31）. The patients of control group were treated with routine therapy only, whereas the patients of treatment group were treated with atorvastatin 20 mg once daily based on routine therapy for 12 weeks. Serum total cholesterol （TC）, triglyceride（TG）, lower density lipid-cholesterol （ LDL-C）, high density lipid-cholesterol （ HDL-C）, TNF-α and IL-6 levels were measured and National Institutes of Health Stroke Scale （NIHSS） was evaluated before and after treatment. Results After treatment, the serum levels of TC, TG, LDL-C,α and IL-6, NIHSS in treatment group were significantly lower than those in control group,TC（4. 214-0.88） mmol/L vs （4.69±0.93） mmol/L,TG（1.12± 0.46） mmol/L vs （1.26±0.42） mmol/L,LDL-C（2. 23±0. 55） mmol/L vs （2.82±0.59） mmol/L,NIHSS（10.56±3.61） marks vs （15.35±3.92） marks,TNF-α （9.95±3.68） btg/L vs （15.42±3.79） μg/L,IL-6（10. 34±2. 81） μg/L vs （14.27±3.12） μg/L. However,the serum level of HDL-C in treatment group was significantly higher than that in control group, （ 1.29 ± 0.38） mmol/L vs （ 1.11 ±0.34） mmol/L （ P 〈 0.05 ）. Conclusion Atorvastatin proves significant effect in neurological function improvement of patients with acute ischemic stroke in normal lipidemia. Its mechanism may be related with reducing the production of TNF-α and IL-6 and inhibiting inflammatory reaction.

关 键 词：脑梗塞 肿瘤坏死因子Α 白细胞介素6 阿托他伐汀 

分 类 号：R743.33[医药卫生—神经病学与精神病学]