腹腔灌注化疗及热化联合治疗恶性腹腔积液的疗效对比分析  

Comparative analysis of curative effect between celiac infusion chemotherapy and thermotherapy combined chemotherapy in the treatment of malignant ascites

作　　者：孔轶[1] 李科[1] 

机构地区：[1]湖南省肿瘤医院肝胆胰内科,湖南长沙410215

出　　处：《中国当代医药》2012年第34期14-16,共3页China Modern Medicine

摘　　要：目的探讨腹腔灌注化疗与热化联合治疗恶性腹腔积液的临床疗效、副反应及并发症的差异。方法收集本院2009年1月～2011年12月经热化联合治疗的恶性腹腔积液患者95例,单纯化疗的恶性腹腔积液患者95例,按照年龄、评分进行配对,比较两组患者治疗前后疗效、Karnofsky评分、骨髓抑制、胃肠道反应等并发症情况。结果热化联合组治疗1个月后腹水控制率为66.3%,治疗2个月后腹水控制率为80.0%,均显著高于单纯化疗组1个月后(47.4%)、2个月后(56.8%)的腹腔积液控制率。热化联合组治疗1个月后KPS评分上升率为59.0%,治疗2个月后上升率为76.8%,均显著高于单纯化疗组1个月后(32.6%)、2个月后(47.4%)的KPS上升率。与热疗相关的主要副反应为脂肪硬节(10.5%)及皮肤红肿(49.5%)。结论热化联合治疗恶性腹腔积液有较好疗效,可明显改善患者生活质量,延长生存期,值得进一步临床推广应用。Objective To explore the difference of curative effect, side-effects and complications between celiac infusion chemotherapy and thermotherapy combined chemotherapy in the treatment of malignant ascites. Methods Ninety five cases of patients with malignant ascites who had received celiac infusion thermotherapy and 95 cases of patients with malignant ascites who had received thermotherapy combined chemotherapy were collected from January 2009 to December 2011 in our hospital, which matched according to the age and score. The curative effect, Karnofsky points, the complications such as bone marrow suppression and gastrointestinal reaction were compared. Results The control rate of ascites after one and two month treated period of the combination group were 66.3% and 80.0% respectively, which were markedly higher than those of the simple treated group （47.4% and 56.8% respectively）. The rise rate of KPS after one and two month treated period of the combination group were 59.0% and 76.8% respectively, which were also signally higher than those of the simple treated group （32.6% and 47.4% respectively）. The side-effects correlated with RFTT were fat necrosis （10.5%） and skin red and swollen （49.5%）. Conclusion Chemotherapy combined thermotherapy for patients with malignant ascites is an effective therapeutics method, and can improve the quality of life, prolong surial for patients, which is worthy of further clinical application.

关 键 词：热疗 化疗 腹腔灌注 恶性腹腔积液 

分 类 号：R730.5[医药卫生—肿瘤]