Malakoplakia of the esophagus caused by human papillomavirus infection  

作　　者：Ya-Li Yang Yu-Cheng Xie Xiao-Ling Li Jing Guo Tao Sun Jing Tang 

机构地区：[1]Department of Pathology,Yunnan Province Second People's Hospital [2]Department of Pathology,Changzhou Traditional Chinese Medical Hospital

出　　处：《World Journal of Gastroenterology》2012年第45期6690-6692,共3页世界胃肠病学杂志（英文版）

摘　　要：Malakoplakia is a rare granulomatous disease probably caused by infection and characterized histologically by Michaelis-Gutmann bodies.We report a more rarely seen case esophageal malakoplakia in a 54-year-old woman.She presented with coughing while eating and drinking.Gastroscopy showed yellow nodules in the esophagus,and endoscopic ultrasonography showed a space-occupying lesion in the substratum of the esophageal mucosa.All findings highly resembled esophageal cancer.Histopathological examination finally indentified this space-occupying lesion as malakoplakia and not cancer.Immunohistochemistry showed that she had human papillomavirus(HPV) infection in the esophagus,which indicates that infection was responsible for the malakoplakia.This is believed to be the first case of malakoplakia in the esophagus,and more importantly,we established that HPV infection was the initiator of esophageal malakoplakia.Malakoplakia is a rare granulomatous disease probably caused by infection and characterized histologically by Michaelis-Gutmann bodies. We report a more rarely seen case esophageal malakoplakia in a 54-year-old woman. She presented with coughing while eating and drinking. Gastroscopy showed yellow nodules in the esophagus, and endoscopic ultrasonography showed a space-occupying lesion in the substratum of the esoph- ageal mucosa. All findings highly resembled esopha- geal cancer. Histopathological examination finally in- dentified this space-occupying lesion as malakoplakia and not cancer. Immunohistochemistry showed that she had human papillomavirus （HPV） infection in the esophagus, which indicates that infection was respon- sible for the malakoplakia. This is believed to be the first case of malakoplakia in the esophagus, and more importantly, we established that HPV infection was the initiator of esophageal malakoplakia.

关 键 词：MALAKOPLAKIA ESOPHAGUS Michaelis-Gut- mann bodies Human papillomavirus infection 

分 类 号：R735.1[医药卫生—肿瘤]