轻度认知功能障碍患者血清胰岛素、空腹血糖的变化  

Alterations of insulin and fasting plasma glucose in patients with mild cognitive impairment

作　　者：吴石星[1] 张长应[1] 谭佩珍[1] 严秋凤[1] 

机构地区：[1]湖南省第二人民医院神经内科,湖南长沙410007

出　　处：《中国当代医药》2012年第36期56-57,共2页China Modern Medicine

摘　　要：目的探讨轻度认知功能障碍患者血清胰岛素、空腹血糖的变化。方法选择2010年7月～2012年7月本院收治的轻度认知功能障碍(MCI)患者63例(MCI组)以及年龄、性别相匹配的健康老年人59例(对照组),以化学发光法检测血清胰岛素水平,以葡萄糖氧化酶法检测空腹血糖。结果与对照组相比,轻度认知功能障碍患者血清胰岛素明显升高[(13.94±5.21)mU/Lvs(10.33±2.67)mU/L],差异有统计学意义(P<0.05);与对照组相比,轻度认知功能障碍患者空腹血糖为[(5.36±1.06)mmol/Lvs(5.24±1.12)mmol/L],差异无统计学意义(P>0.05)。结论轻度认知功能障碍患者血清胰岛素升高,高胰岛素血症可能是轻度认知功能障碍的危险因素。Objective To explore the alterations of insulin and fasting plasma glucose in patients with mild cognitive impairment（MCI）.Methods Sixty three inpatients with MCI（MCI group） and 59 healthy elders matching with age and gender（control group） were enrolled from July 2010 to July 2012,the levels of insulin were measured by chemiluminescence,the levels of fasting plasma glucose were measured by glucose oxidase method in MCI group and control group.Results The level of insulin increased significantly in MCI group[（13.94±5.21） mmol/L],compared with control group[（10.33±2.67）mmol/L],the difference was statistically significant（P 〈0.05）;While the level of fasting plasma glucose in MCI group was（5.36±1.06） mmol/L,compared with the control group[（5.24±1.12） mmol/L],the difference was not statistically significant（P 〈0.05）.Conclusion The level of insulin increased in patients with MCI,perhaps hyperinsulinemia is the risk factors for MCI.

关 键 词：轻度认知功能障碍 胰岛素 空腹血糖 研究 

分 类 号：R74[医药卫生—神经病学与精神病学]