单分散PS/PGMA核-壳型高分子微球的制备与表征  

Preparation and characterization of monodisperse PS/PGMA core-shell polymer microspheres

作　　者：段殷[1] 左锋[2] 柴宏森[2] 刘建华 王冬梅[1] 徐亮[1] 周晶[1] 

机构地区：[1]天津医科大学药学院天津市临床药物关键技术重点实验室,天津300070 [2]天津市出入境检验检疫局,天津300457 [3]湖北沙隆达股份有限公司,湖北434001

出　　处：《天津医科大学学报》2012年第4期416-418,421,共4页Journal of Tianjin Medical University

基　　金：教育部博士点基金资助项目(201012021200033);天津市高等学校科技发展基金计划项目(20070604)

摘　　要：目的:采用种子聚合法将甲基丙烯酸缩水甘油酯(GMA)包覆在聚苯乙烯(PS)种子上,制备出纳米级、单分散的核-壳型PS/PGMA高分子微球。方法:考察了引发剂(过硫酸钾)、表面活性剂(十二烷基磺酸钠)、单体(GMA)的用量和PS种子微球粒径等条件对PS/PGMA纳米微球粒径的影响。采用透射电子显微镜(TEM)、红外光谱(IR)等手段对样品的结构及形貌进行了表征。结果:通过优化制备条件,可以实现对微球粒径的调控,IR测定显示制备的微球含有PGMA与PS的特征官能团,TEM可看出所制微球球形度较好,具有清晰的壳-核型结构。结论:该方法制得PS/PGMA微球表面富含环氧基,因此更易于表面改性,克服了单一PS微球不易改性的缺点。Objective： To fabricate monodisperse poly-glycidyl methacrylate （PGMA） coated polystyrene （IS） （PS/PGMA） core-shell polymer nanoparticles by seeded polymerization. Methods： The influences of concentrations of initiator （potassium persulfate）, surfactant （sodium dodecyl sulfate） and monomer （GMA）＇ s concentration as well as PS seed＇ s diameter on the size and morphology of the PS/PGMA mierospheres were investigated. Transmission electron microscopy （TEM） and infrared spectroscopy （IR） were used to characterize the prepared PS/PGMA microspheres. Results： The size of microspheres could be controlled by changing and optimizing the reaction condi- tions. IR showed that the GMA was really modified on the PS seeds. The prepared PS/PGMA was found by TEM with good spherical and apparent core-shell structure. Conclusion： The GMA-eoated PS microspheres can promise convenient surface modification and over- come the disadvantage of difficult surface functionalization of common PS microspheres.

关 键 词：单分散 核-壳型 PS PGMA复合高分子微球 

分 类 号：R914[医药卫生—药物化学]