天麻细粉片在高血脂大鼠模型中的降血脂实验研究  

Experimental study of the lipid-lowering activity of Gastrodina Commen-Pulverization Tablets in the rat model of hyperlipidemia

作　　者：于滨[1] 李永利[2] 左增艳[1] 李峥[1] 孔维佳[1] 

机构地区：[1]中国医学科学院医药生物技术研究所,北京100050 [2]河南省疾病预防控制中心,河南郑州450016

出　　处：《中国医药导报》2012年第36期5-6,共2页China Medical Herald

基　　金：中央级公益性科研院所基本科研业务费专项资助项目(项目编号:IMBF20060505)

摘　　要：目的研究天麻细粉片剂在高血脂大鼠模型中降血脂活性。方法采用雄性SD大鼠,以高脂高胆固醇饲料喂养,观察天麻细粉片对大鼠血脂升高的预防作用。实验设正常对照组、高脂模型对照组、天麻细粉片剂0.56、1.12、2.50 g/kg组,共5组,疗程30 d。实验前后检测血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)。结果天麻细粉片2.50 g/kg剂量组能预防大鼠血清中总胆固醇(TC)升高,与高脂模型对照组比较,差异有统计学意义(P<0.05),天麻细粉片三个剂量组均能预防大鼠血清中的三酰甘油(TG)升高,与高脂模型对照组比较,差异有高度统计学意义(P<0.01)。结论天麻细粉片在高血脂大鼠模型中具有降血脂作用。Objective To study the lipid-lowering activity of Gastrodina Commen-Pulverization Tablets in the rat model of hyperlipidemia. Methods Male SD rats were fed with a high fat and high cholesterol （HFHC） diet to observe the suppress- ing effect of Gastrodina Commen-Pulverization Tablets on hyperlipidemia. The animals were divided into 5 groups, they were the normal diet control group, HFHC control group, and Gastrodina Commen-Pulverization Tablets 0.56, 1.12 and 2.50 g/kg groups, respectively. The treatment lasted for 30 days. Serum total cholesterol tiC）, triglyceride （FG） and high densi- ty lipoprotein-cfiolesterol （HDL-C） levels were determined before and after experiment. Results 2.50 g/kg of Gastrodina Commen-Pulverization Tablets prevented the increase of serum TC in the rats, there was signifcant difference compared with the HFHC group （P 〈 0.05）. 0.56, 1.12, and 2.50 g/kg of Gastrodina Commen-Pulverization Tablets prevented the in- crease of serum TG in the rats, there was statistically significant difference compared with the HFHC group （P 〈 0.01）. Conclusion Gastrodina Commen-Pulverization Tablets have lipid-lowering efficacy in the rat model of hyperlipidemia.

关 键 词：天麻细粉 大鼠 高脂血症 

分 类 号：R965[医药卫生—药理学]