p53在人和小鼠口腔鳞状细胞癌组织中表达的比较  

Comparison of p53 expression in oral squamous cell carcinoma of human and mouse

作　　者：闭似嫦[1] 于大海[1] 黎明武[1] 韦堡升[1] 

机构地区：[1]广西医科大学附属口腔医院口腔颌面外科,南宁530021

出　　处：《中国临床新医学》2012年第12期1110-1112,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西卫生厅重点科研课题(编号:桂卫重2010081)

摘　　要：目的比较p53在人和小鼠正常口腔黏膜、口腔异常增生组织、口腔鳞状细胞癌(简称鳞癌)组织中的表达及意义。方法采用免疫组织化学方法分别检测人和小鼠各8例口腔正常黏膜,各8例口腔异常增生组织,各8例口腔鳞癌组织中p53的表达情况。结果人口腔正常黏膜p53表达率为0.0%(0/8),口腔异常增生组织p53表达率37.5%(3/8)、口腔鳞癌p53表达率62.5%(5/8);小鼠正常口腔黏膜p53表达率为0(0/6),口腔异常增生组织p53表达率为50.0%(4/8),口腔鳞癌p53表达率为75.0%(6/8)。结论 p53蛋白阳性表达在人和小鼠保持一致性,均随病理恶性程度升高而增加。小鼠口腔鳞癌模型与人类口腔鳞癌的发生发展具有相似性。Objective To compare 1o53 expression in oral squamous cell carcinoma of human and mouse. Methods Immunohistochemical method was used to detect the expression of p53 gene in 8 cases of normal oral mu- cosa, 8 oases of oral dysplasia and 8 oases of oral squamous cell carcinoma （OSCC） in human and mouse, respec- tively. Results In human normal oral mucosa, dysplasia, and OSCC, the positive p53 protein expression rates were 0. 0%, 37.5 %, 62. 5 %, respectively ; while in mouse were 0. 0% , 50. 0% , 75.0% , respectively. Conclusion There is the similar expression of p53 protein between human and mouse in same pathological stages. The develop- ment of the oral squamous cell carcinoma of the human and mouse may be similar to each other.

关 键 词：P53 口腔异常增生组织 口腔鳞癌 免疫组织化学技术 小鼠 人 

分 类 号：R739.8[医药卫生—肿瘤]