肝硬化患者凝血指标、血清前白蛋白和总胆汁酸检测的临床价值  

Clinical Value of Coagulation Indices,Serum Prealbumin and Total Bile Acid in Patients withlive Cirrhosis

作　　者：郑三菊[1] 王崇慧[2] 

机构地区：[1]湖北医药学院附属人民医院消毒供应宣,十堰442000 [2]湖北医药学院附属人民医院肝病科,十堰442000

出　　处：《临床消化病杂志》2012年第6期340-342,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨检测肝硬化患者凝血指标、血清前白蛋白(PA)和总胆汁酸(TBA)的临床价值。方法检测了165例肝硬化患者(肝硬化组)和50例健康者(对照组)的凝血功能指标(PT、aPTT、TF、Fbg)和肝功能(ALT、TBIL、PA、ALB、TBA),并根据肝功能Child-Pugh分级进行分组比较。结果与对照组比较,肝硬化组PT,aPTT、TT延长,Fbg降低,ALT、TBIL、TBA升高,PA、ALB降低(P<0.01);随着患者Child-Pugh分级增高,其PT,aPTT、TT逐渐延长,Fbg逐渐降低,TBIL TBA逐渐升高,PA、ALB逐渐降低,不同级别间差异有统计学意义(P<0.05,P<0.01)。结论凝血指标、血清前白蛋白和总胆汁酸反映患者肝脏的合成功能,可作为评估肝硬化患者病情及预后的有效指标。Objective To investigate the clinical value of coagulation indices, serum prealbumin （PA） and total bile acid（TBA） in patients with liver cirrhosis Methods The coagulation indices （FF, aPTF, T＇F, Fbg）and liver function （ALT, TBIL, PA, ALB, TBA） in 165 cases of patients with liver cirrhosis （ cirrhosis group） and 50 healthy peoples （ control group） were detected the results between groups after cirrhosis Child-Pugh classification were compared. Results Comparing with healetby group, PT, aPTF, TI＇ prolonged, Fbg declined, ALT, TBIL, TBA increased and PA, ALB decreased in cirrhosis group （P 〈 0.01 ）. PT, aPTI＇,TF prolonged, Fbg declined,TBIL,TBA increased and PA, ALB decreased gradually in patients with the in- crease of their Child- Pugh grades, and there were statistically significant differences between different grades （ P 〈 0.05, P 〈 0.01 ）. Conclusion The levels of coagulation indices, serum prealbumin and total bile acid level reflect synthetic function of live. They can be used as important indicators to assess the state and prognosis of patients with liver cirrhosis.

关 键 词：肝硬化 凝血指标 前白蛋白 总胆汁酸 Child—Pugh分级 

分 类 号：R575.2[医药卫生—消化系统]