Syk与VEGF-C在乳腺癌中的表达及临床意义  

Expression and Association of VEGF-C and Syk in Patients with Breast Cancer

作　　者：张大坤[1] 徐建中[1] 付晓君[1] 卢冉[1] 

机构地区：[1]蚌埠医学院第一附属医院普外科,安徽蚌埠233004

出　　处：《解剖与临床》2012年第6期474-477,共4页Anatomy and Clinics

摘　　要：目的：检测Syk与VEGF-C在乳腺癌组织中的表达情况，探讨它们与乳腺癌病理、临床特征间的关系。方法：应用免疫组化Elvsion法检测64例乳腺癌患者手术切除的癌组织和癌周正常组织中Syk和VEGF．C的表达情况。结果：Syk在正常组织中表达的阳性率为90％，在乳腺癌组织中阳性表达率为59．37％；VEGF-C在正常组织中阳性表达率为0．0％，在乳腺癌组织中的阳性表达率为76．56％；二者比较差异均有统计学意义（P〈0．05）。Syk与VEGF-C表达水平均与乳腺癌病理分级、临床分期、淋巴结转移有关（P〈0．05）。结论：联合检测乳腺癌中Syk和VEGF-C表达水平，对乳腺癌的早期发现及预后判断有一定参考价值。Objective：To study the relationship between the expression of spleen tyosine kinase （Syk） and vascular endothelial growth factor-c （VEGF-C） and clinicopathological features in breast cancer. Meth- ods：Expression of Syk and VEGF-C in 64 breast cancer and tumor adjacent tissues were detected by immuno- histochemical method. Results：The positive expression rate of Syk in normal tissues was 90.00% and it was 59.37% in tumor tissues, the positive expression rate of VEGF-C in normal tissues was 0.0%, and it was 76.56% in tumor tissues. Statistical analysis indicated a significant difference （P 〈0.05）. Syk and VEGF-C expression in cancerous samples was related to pathology grade, TNM stage and lymph node metastasis （ P 〈 0.05 ）. Conclusions： The combination examination of Syk and VEGF-C may be valuable for early diagnosis and prognosis predict in breast cancer.

关 键 词：乳腺癌 血管内皮生长因子-C 脾酪氨酸激酶 癌基因 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤] R446.6[医药卫生—临床医学]