表皮生长因子对游离毛囊生长的影响  

Effects of Epidermal Growth Factor on Human Hair Follicle Growth in vitro

作　　者：杨淑霞[1] 钟志红[1] 秦俭[1] 马圣清[1] 武玲慎[1] 

机构地区：[1]北京医科大学第一医院皮肤科,100034

出　　处：《中华皮肤科杂志》2000年第2期99-101,共3页Chinese Journal of Dermatology

基　　金：宝洁公司资助课题

摘　　要：目的 通过毛囊器官培养观察表皮生长因子（ EGF）对人头皮毛囊生长的影响。方法 用 Williams E无血清培养基进行人头皮毛囊游离培养，分为 2组， EGF组（ 43根）和对照组（ 43根）。结果 EGF 20μ g/L组在加药后 1～ 3 d毛干平均生长 0.22 mm/d，对照组平均生长 0.16 mm/d。Objective To investigate the effects of epidermal growth factor (EGF) on hair follicle growth. Methods Cultured human hair follicles were divided into two groups: EGF- treated group (EGF 20 ng/mL) and control group. The length and morphology of follicles were measured by inverted microscope daily. 3H- leucine incorporation and histologic studies were applied. Results The rates of hair shaft and hair follicle elongation significantly increased in the EGF- treated group during day 1 to day 3 in comparison with the control group. Histologically, the cells of the lower outer root sheath were thickened and club hair- like structure was formed. 3H- leucine incorporation showed that the radioactivity in hair follicle epithelium was higher in EGF- treated group (370 c/min)than that in control group(271.14 c/min) (P

关 键 词：毛囊 器官培养 表皮生长因子 尿抑胃素 

分 类 号：R363[医药卫生—病理学]