维生素D受体基因FokI多态性与前列腺癌易感性的Meta分析  

Polymorphism of vitamin D receptor gene FokI and susceptibility of prostatic cancer:a Meta-analysis

作　　者：曹加[1] 李夏西[1] 侯祺[2] 李荣[1] 罗荣城[1] 

机构地区：[1]南方医科大学南方医院 肿瘤中心 [2]南方医科大学南方医院 泌尿外科,广州510515

出　　处：《中南大学学报（医学版）》2012年第12期1215-1220,共6页Journal of Central South University ：Medical Science

摘　　要：目的：定量分析维生素D受体基因（VDR）单核苷酸多态性位点FokI（rs2228570）的多态性与前列腺癌易感性的关系。方法：检索Pubmed,EMBase,CBM,CNKI,VIP,万方数据平台从建库到2011年5月的文献,对符合本实验纳入标准和排除标准的随机对照临床研究,运用RevMan5.0.0软件进行Meta分析,Stata11.0软件进行Begg＇s检验。结果：共纳入10篇文献,累积样本量为8360例,其中病例组3749例,对照组4611例。定量合成分析未见VDR FokI位点的多态性与前列腺癌易感性有显著关联（等位基因F对f：OR=1.00,95%CI=0.94~1.06,P=0.96;基因型FF/Ff对ff：OR=1.04,95%CI=0.93~1.51,P=0.48;基因型FF对Ff/ff：OR=0.97,95%CI=0.89~1.06,P=0.53）。以印度人群为对象的一篇研究提示等位基因F是前列腺癌的危险因素,但Begg＇s检验显示该研究存在较大的发表偏倚。对全体人群按人种进行亚组分析,均未得到VDR FokI位点的多态性与前列腺癌易感性显著性相关（等位基因F对f：白种人OR=0.91,95%CI=0.88~1.02,P=0.17;黄种人OR=1.09,95%CI=0.95~1.24,P=0.22;印度人OR=1.91,95%CI=1.30~2.81,P=0.0009）。结论：VDR FokI位点等位基因F可能为欧美高加索人前列腺癌的保护因素。Objective： To quantitatively investigate the association between the polymorphism of FokI of the VDR gene and the susceptibility of prostatic cancer.Methods： Databases of Pubmed,EMBase,CBM,CNKI,VIP,and Wanfang Data were retrieved from the date they formed till May 2011.All randomized controlled clinical trials which matched both the inclusive criteria and exclusive criteria were subjected to meta-analysis,conducted on Revman 5.0.0 software.Stata 11.0 software was employed to process Begg’s test.Results： Ten studies were included.Total sample cases were 8360,with 3749 cases in the patient group and 4611 cases in the control group,respectively.The quantitative analysis showed there were no significantly differences between the polymorphism of VDR FokI alleles and the susceptibility of prostatic cancer（allele F to f： OR=1.00,95% CI=0.94-1.06,P=0.96;genotypes FF/Ff to ff： OR=1.04,95% CI=0.93-1.51,P=0.48;genotypes FF to Ff/ff： OR=0.97,95% CI=0.89-1.06,P=0.53）.Though one research on Indian people indicated that allele F was a risk factor for prostatic cancer,in Begg’s test we observed relatively high publication bias.The subgroup analysis showed there were no significantly differences between the polymorphism of VDR FokI alleles and the susceptibility of prostatic cancer（allele F to f,white race： OR=0.91,95% CI=0.88-1.02,P=0.17;yellow race： OR=1.09,95% CI=0.95-1.24,P=0.22;Indian： OR=1.91,95% CI=1.30-2.81,P=0.0009）.Conclusion： VDR FokI allele F might be a protective factor for European and American Caucasians.

关 键 词：维生素D受体 FokI 单核苷酸多态性 前列腺癌 META分析 

分 类 号：R737.25[医药卫生—肿瘤]