去氢骆驼蓬碱软膏对小鼠上皮细胞 有丝分裂及表皮角化的影响  

Effect of Ung. of harmine on mouse epithelial mitosis and epidermal keratinization

作　　者：李宇晶[1] 陈蔚茹 王根厚[3] 

机构地区：[1]新疆医科大学基础医学院组织胚胎学教研室,新疆乌鲁木齐830054 [2]天津民航学院,天津300000 [3]新疆医科大学第一附属医院烧伤整形科

出　　处：《新疆医科大学学报》2000年第1期8-9,共2页Journal of Xinjiang Medical University

基　　金：自治区科委重点科学研究资助!G9531007

摘　　要：了解去氢骆驼蓬碱软膏对雌激素周期小鼠阴道上皮模型及鼠尾鳞片表皮模型的作用，为开发新的治疗银屑病药物提供初步的实验依据。方法：制备雌激素周期小鼠阴道上皮模型及鼠尾鳞片表皮模型，用光学显微镜观察分析基底细胞中有丝分裂数及颗粒层鳞片数。结果；与对照组相比，去氢骆驼蓬碱软膏对两个实验模型的作用均存在显著差异（Ｐ＜０．０１）。结论：去氢骆驼蓬碱软膏能抑制增殖活跃的上皮细胞并促使表皮角化完全，起到治疗银屑病的作用。Objective: To explore the effects of Ung. 0.4% and 0.2% of harmine on mouse vaginal epithelium and scale epidermis of mouse tail. Methods: Forming the model of mouse vaginal epithelium and scale epidermis of mouse tail, using light microscope to observe the epithelial mitosis and epidermal keratinization respectively. Results: Compared with the normal group, the effects of Ung. 0.4% and 0.2% of harmine on mouse vaginal epithelium and scale epidemics of mouse tail were obvious (P<0.01). Conclusion: Ung. of harmine could significantly inhabite the mitosis in epithelium, and promote the formation of granular layer in scale epidermis.

关 键 词：去氢骆驼蓬碱 小鼠 皮皮细胞 有丝分裂 银屑病 

分 类 号：R758.630.5[医药卫生—皮肤病学与性病学] R986[医药卫生—临床医学]