正交试验法优选黄连浸膏的喷雾干燥工艺  

Optimization of Spray Drying Process of Coptidis Rhizoma Extract by Orthogonal Test

作　　者：吕子明[1,2] 于向红 陈凯 刘晓燕 梁俊清 屠鹏飞[1] 

机构地区：[1]北京大学药学院,天然药物及仿生药物国家重点实验室,北京100191 [2]北京以岭药业有限公司,北京100027 [3]北京华众思康医药技术有限公司,北京102209

出　　处：《中国实验方剂学杂志》2013年第1期10-12,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项(2011ZX09401-020)

摘　　要：目的:优选黄连浸膏的喷雾干燥工艺。方法:采用L9(34)正交设计法,以喷干粉出粉量、小檗碱含量和含水量为指标,考察进风口温度、出风口温度、浸膏比重对黄连浸膏喷雾干燥工艺的影响。结果:优选的喷雾干燥工艺为进风口温度180℃,出风口温度80℃,浸膏比重1.15。结论:该优选工艺合理、稳定,可为黄连的工业化生产提供实验依据。Objective： To investigate spray drying process of Coptidis Rhizoma extract. Method： With the amount of spray dry powder, the content of berberine and moisture content as indexes, effect of air inlet temperature, outlet temperature and extract specific gravity on spray drying process of Coptidis Rhizoma extract was investigated by orthogonal test. Result： Optimal spray drying process was： air inlet temperature 180 ℃, outlet temperature 80 ℃ and extract specific gravity of 1.15. Conclusion： This optimized process was rational and stable, it could provide experimental basis for industrial production of Coptidis Rhizoma.

关 键 词：正交试验 喷雾干燥 黄连浸膏 出粉量 水分 小檗碱 

分 类 号：R283.6[医药卫生—中药学]