利培酮、氟哌啶醇对血浆泌乳素影响及其与疗效的关系  

Effects of Risperidone and Haloperidal Treatment on the Plasma Prolactin Levels and their Relationship with Clinical Efficacy

作　　者：张向阳[1] 周东丰[1] 沈渔 张培琰[2] 成秀芳[2] 李道[2] 南振国[2] 白京生[2] 石夏明[2] 陈建[2] 张艳萍[2] 管振全[1] 

机构地区：[1]北京大学精神卫生研究所,100083 [2]北京回龙观医院

出　　处：《中国心理卫生杂志》2000年第4期276-278,共3页Chinese Mental Health Journal

摘　　要：目的 :研究典型、非典型抗精神病药对精神分裂症患者血浆泌乳素 (PRL)水平的影响及其与疗效的关系。方法 :选择符合ICD— 10和CCMD - 2 -R诊断标准的精神分裂症患者 ,按双盲、随机法分为利培酮组和氟哌醇组 ,治疗 12周。采用阳性和阴性症状量表 (PASS)在治疗前后分别评定一次 ;用放射免疫法在治疗前后测定血浆PRL浓度。结果 :治疗前、后两组在PANSS总分及其因子分上均无显著差异 ,但利培酮组症状改善者明显多于氟哌啶醇组 (X2 =3 86 ,p <0 0 5 )。治疗后PRL水平较高、治疗前后差异较大或治疗前PRL水平较高者 ,疗效较好 ,尤其是阳性症状改善明显。结论 :利培酮和氟哌啶醇治疗均明显增加血浆PRL水平 ;而且治疗前、后血浆PRL水平与疗效相关 。Objective: To study the effects of typical and atypical antipsychotic drugs on the plasma prolactin level and their relationship with clinical efficacy Methods: Sixty patients who met the criteria of ICD-10 and CCMD-2-R for schizophrenia were randomly divided into two subgroups receiving double-blinded treatment of risperidone and haloperidal respectively for 12 weeks Positive and Negative symptoms Scale (PANSS) was used to assess the psychopathology before and after the treatment Blood samples were collected at the beginning and end of treatment and plasma prolactin was detected in a double-blinded procedure by radioimmunoassay (RIA) Results: The total score and sub-scores of PANSS before and after the treatment had no significant difference between two groups But the patients acquiring improvement in risperidone group were more than those in haloperidal group (x 2=3 86, p<0 05) The patients with high level of prolactin before the treatment or with a larger increase of prolactin had better efficacy, especially the improvement of the positive symptoms Conclusions: Both risperidone and haloperidal increase the plasma prolactin levels significantly The changes of plasma prolactin level are correlated with treatment efficacy, especially the improvement of positive symptoms

关 键 词：精神分裂症 泌纱 利培酮 氟哌啶醇 疗效 治疗 

分 类 号：R749.305[医药卫生—神经病学与精神病学]