乙型肝炎表面抗原阳性肝硬变220例  

Characteristics of 220 case of HBsAg positive hepatic cirrhosis

作　　者：金海燕[1] 郑日男[1] 姜美子[2] 梁辉[1] 

机构地区：[1]延边大学医学院附属医院消化内科,吉林延吉133000 [2]延边大学医学院附属医院神经内科,吉林延吉133000

出　　处：《延边大学医学学报》2000年第2期118-119,共2页Journal of Medical Science Yanbian University

摘　　要：[目的 ]探讨乙型肝炎表面抗原阳性肝硬变的特点 .[方法 ]检测 2 2 0例乙型肝炎表面抗原阳性肝硬变患者乙型肝炎病毒标志物及乙型肝炎病毒DNA .[结果 ]乙型肝炎e抗原缺失者 148例 ,占 6 7% ,乙型肝炎e抗原阳性者 72例 ,占32 % .乙型肝炎e抗原缺失者乙型肝炎病毒DNA阳性率为 5 9% (77例 ) ,乙型肝炎e抗原阳性者为 40 % (5 3例 ) .乙型肝炎表面抗原、乙型肝炎核心抗体阳性感染模式出现率最高 ,为 38% .[结论 ]乙型肝炎表面抗原阳性肝硬变化患者e抗原缺失者居多 ,且病毒复制明显 .OBJECTIVE To investigate the characteristics of HBsAg positive hepatic cirrhosis. METHODS Using ELISA and polymerase chain reaction, hepatitis B virus serological marker and HBV DNA was detected respectively in 220 cases of HBsAg positive hepatic cirrhosis. RESULTS 148 cases (67%) were absent of HBeAg and 72 cases (32%) were HBeAg positive. The positive rate of HBV DNA in HBeAg absent patients was 59%(77 cases) and the one in HBeAg positive patients was 40%(53 cases). The patients with HBsAg and HBcAb positive were of highest appearing rate (38%) in different model of HBV. CONCLUSION The HBeAg absent patients were major in HBsAg positive hepatic cirrhosis and the virus replicated obviously.

关 键 词：肝硬变 乙型肝炎 表面抗的阳性 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]