Clinical Evaluation of Pranoprofen Combined with Fluorometholone Eye Drops on Postoperative Reaction of Corneal Cross-linking  

作　　者：Xu Pang Zhengjun Fan Xiujun Peng Hongzhen Jia Tengfei Wu 

机构地区：[1]Cadet Corps, Postgraduate Medical School,PLA General Hospital [2]Department of Ophthalmology,Navy General Hospital

出　　处：《Eye Science》2012年第4期173-177,共5页眼科学报（英文版）

摘　　要：Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.Purpose： To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflam- mation after corneal cross-linking （CXL）. Methods： Twenty-seven patients （38 eyes） with keratoconus undergoing CXL were examined and randomly divided into control （12 cases; 18 eyes） and experimental groups （15 cas- es; 20 eyes）. The patients in the control group were given fluorometholone eye drops, and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops. Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results： At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group （P〈0.05）, but there was no significant difference on 5 to 7 days postoperatively （P〉0.05）. The average degree of haze in the experimental group was sig- nificantly lower than that in the control group 1 month after surgery （P〈0.05）, but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with 〉20 mmHg intraocular pressure in the control group. Conclusion： The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response, alleviate corneal irritation at early stage after CXL, effectively prevent and control the average of haze, and reduce the incidence of steroid-induced ocular hypertension after surgery.

关 键 词：交联反应 滴眼液 角膜 氟 评价 临床 眼睛 炎症反应 

分 类 号：R779.63[医药卫生—眼科]