Efficacy of Carbamazepine Combined with Botulinum Toxin A in the Treatment of Blepharospasm and Hemifacial Spasm  

作　　者：Xianhua Li Shaochun Lin Yanfei Hu Liya Liu Jubo Liu Yichun Hong 

机构地区：[1]Department of Opthalmology,the First Rongjun Hospital of Guangdong Province [2]State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University [3]Department of Opthalmology,the First Municipal People's Hospital of Guangzhou

出　　处：《Eye Science》2012年第4期178-181,共4页眼科学报（英文版）

基　　金：The Science and Technology Projects of GuangdongProvince,China (2010B060500006)

摘　　要：Purpose:To observe the efficacy of the combined treatment of carbamazepine and botulinum toxin A for blepharospasm and hemifacial spasm. Methods:Fifty-eight patients with either blepharospasm or hemifacial spasm were randomly divided into treatment and control groups. In the treatment group, 30 patients were administered with local intramuscular injections of botulinum toxin A and oral carbamazepine 100 mg/time,3 times/day for 60 days. Twenty-eight subjects in the control group under-went local intramuscular injections of botulinum toxin A only. Results:After combined treatment, the complete remission rate was 90%, which was significantly higher than that of the of the control group (67.9% , P<0.05,χ2 =4.733). However, no statistical significance was noted regarding the duration of therapeutic effects between the treatment group (range 14～40 weeks; 19.2 weeks on average) and control group (range 12～36 weeks; 18 weeks on average). Conclusion:The combined therapy of carbamazepine and topical injections of botulinum toxin A had increased efficacy in the treatment of blepharospasm or hemifacial spasm, but had no significant effect in terms of the duration of the therapeutic effect.Purpose： To observe the efficacy of the combined treatment of carbamazepine and botulinum toxin A for blepharospasm and hemifacial spasm. Methods： Fifty-eight patients with either blepharospasm or hemifacial spasm were randomly divided into treatment and control groups. In the treatment group, 30 patients were administered with local intramuscular injections of botulinum toxin A and oral carbamazepine 100 mg/time, 3 times/day for 60 days. Twenty-eight subjects in the control group under- went local intramuscular injections of botulinum toxin A only. Results： After combined treatment, the complete remission rate was 90%, which was significantly higher than that of the of the control group （67.9%, P〈0.05,X2=4.733）. However, no statistical significance was noted regarding the duration of therapeutic effects between the treatment group （range 14-40 weeks; 19.2 weeks on average） and control group （range 12- 36 weeks; 18 weeks on average）. Conclusion： The combined therapy of carbamazepine and topical injections of botulinum toxin A had increased efficacy in the treatment of blepharospasm or hemifacial spasm, but had no significant effect in terms of the duration of the therapeutic effect.

关 键 词：A型肉毒毒素 综合治疗 卡马西平 肌痉挛 眼睑 和面 功效 肉毒杆菌毒素 

分 类 号：R777.1[医药卫生—眼科]