NGF和Svate-3对多发性脑梗塞大鼠纹旁区神经元作用的实验研究  

Effects of Nerve Growth Factor and Svate-3 on Parastriate Area Neurons in Rats with Multiple Cerebral Infarction

作　　者：刘晓湘[1] 李东培[1] 方秀斌[1] 高杰[1] 

机构地区：[1]中国医科大学基础医学院解剖学教研室,沈阳110001

出　　处：《中国医科大学学报》2000年第3期175-176,179,共3页Journal of China Medical University

基　　金：辽宁省自然科学基金!6190 19

摘　　要：目的 :探讨多发性脑梗塞 (MCI)大鼠纹旁区一氧化氮合酶 (NOS)的变化及神经生长因子 (NGF)和精制蝮蛇抗栓酶 3号 (Svate- 3)联合应用对 MCI大鼠纹旁区的作用。方法 :选用 Wistar大鼠 ,应用微栓子栓塞阻断法建立多发性脑梗塞性缺血模型 ,用 NADPH- d组化方法、透射电镜技术并结合显微图像分析技术。结果 :实验组 NOS阳性反应物平均灰度值与实验对照组比较明显降低 (P <0 .0 1)。结论 :NGF和 Svate- 3联合应用可使 MCI大鼠纹旁区 NOS阳性反应物明显增多 ,对Objective:Our purpose was to explore the effects of combined application of nerve growth factor (NGF) and Svate 3 on parastriate area neurons in rats with multiple cerebral infarction(MCI) through the changes of nitric oxide synthase (NOS). Methods: We used NADPH d histochemistry, transmission electron microscopy, and quantitative method of micro image analysis system. Results: The average grey value of NOS positive reactive product in experimental group is lower than that in control group (P<0.01). Conclusion: NGF and Svate 3 have effects on the recovery of parastriate area neurons in MCI rats. The results might provide the theoretical basis for further research and treatment of MCI in clinic.

关 键 词：多发性脑梗塞 神经生长因子 SVATE-3 NOS 

分 类 号：R743.33[医药卫生—神经病学与精神病学]