女性肺腺癌危险因素分析  

The Risk Factors of Female Lung Adenocarcinoma

作　　者：周宝森[1] 王天爵[1] 张群弟[1] 关鹏[1] JosephM.Wu 

机构地区：[1]中国医科大学流行病学教研室,沈阳110001 [2]纽约医学院生化与分子生物学系

出　　处：《中国公共卫生》2000年第6期536-539,共4页Chinese Journal of Public Health

基　　金：国家"八五"攻关;CenterforIndoorAirResearch资助

摘　　要：1991年 4月至 1995年 12月在沈阳市区开展了以健康人群为基础的肺腺癌病例对照研究。共调查原发性肺腺癌病例 72例 ,年龄为 35～ 6 9岁 ,有Mantel Haenszel法与多因素Logistic模型对资料进行分析 ,结果表明 :烹调油烟、肺癌家族史、月薪收入、活产数、β -胡萝卜素摄入量和维生素E与肺腺癌发病有关。对其中烹调油烟按等级数量化后 ,其OR值分别为 1 33、7 33、1 6 7,存在剂量效应关系。对其暴露水平调整后 ,暴露于烹调油烟的危险性为 4 5 3倍。肺癌家族史的危险度为 7 6 5。摄入蔬菜、水果中的 β -胡萝卜素为保护因素 ,保护度为 0 38。调整混杂因素后对女性肺腺癌的多变量Logistic回归 。The aim of the study was to explore the risk factors of pulmonary adenocarcinoma among female in Shenyang of China.A casecontrol study based on general population was designed and multivariable logistic regression model was applied.72 pulmonary adenocacinoma cases of new diagnosis duration from January,1991 to December,1995,ages 35～69,were studied by 1∶1 match.The results showed that the cooking fumes,family history of lung cancer,economic income,numbers of live births and vitamin E were significant risk factors assoiated with adenocarcinoma of the lung.The βcarotene of intak from vegetables and fruits was a protective factor and protective level was 028(95% CI,0.12～0.69),Analysis of the relationship between the indoor air pollution and adenocarcinoma of the lung showed that the risk increased with the level of exposure to cooking fumes increased.The odds ratioin the different levels were 1.33,7.33,1.67 respectively and indicated the doserespond relationship(tend p=0.006).The other important factor was the family history of lung cancer,the OR was 7.65 folds(95% CI,0.90～169.84).The result of multivariable logisic regression model for pulmonary adenocarcinoma among female showed the same results after adjusting confounding factors.

关 键 词：肺腺癌 环境烟草烟雾 危险因素 室内空气污染 

分 类 号：R734.202[医药卫生—肿瘤]