性激素及其受体与膀胱癌  

Relationship between Sex Hormone,Sex Hormone Receptors and Bladder Cancer

作　　者：米华[1] 甘俊常[1] 刘天长[1] 李盛宽[1] 黄伟华[1] 

机构地区：[1]广西医科大学第一附属医院泌尿外科,南宁530021

出　　处：《肿瘤防治研究》2000年第3期167-169,共3页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨性激素及其受体与膀胱癌的关系。方法　用放免法测定 2 9例膀胱癌患者手术前后的血清睾酮 (T)、雌二醇 (E2 )、孕酮 (P)、并测定 2 5例健康献血员的T、E2 、P作对照。同时用S P免疫组化法检测 2 8例膀胱癌组织、 2 0例癌旁组织及 2 1例正常膀胱组织的雄激素受体 (AR)、雌激素受体 (ER)和孕激素受体 (PR)结果　和对照组相比 ,膀胱癌患者的T和T E2 比值升高 ,E2 降低。手术后T和T E2 比值下降 ,E2 升高。膀胱癌组织的AR阳性率高于正常膀胱组织。结论　膀胱癌患者存在明显的性激素比例失调 ,高雄激素和低雌激素水平可能与膀胱癌的发病有关。Objective To study the relationship between sex hormone,sex hormone receptors and bladder cancer.Methods Serum testosterone(T),estradiol(E 2),progesterone(P) were determined in 29 patients with bladder cancer,and their changes before and after operation were observed.and in 25 healthy men as the control group.Androgen receptor(AR),estrogen receptor(ER),progesterone receptor(PR) were investigated in 28 cases of bladder cancer tissue and 21 cases of adjacent normal bladder tissue and 25 cases of normal bladder tissue.Results T and T/E 2 were higher and E 2 was lower than those in the control group.after operation,T and T/E 2 were reduced and E 2 was increased.The positive rate of the AR in bladder cancer tissue was significantly higher than that in normal bladder tissue.Conclusion There was a significant imbalance of sex hormone in patients with bladder cancer,which was improved after operation,It is likely that bladder cancer is correlated to the imbalance of sex hormore.

关 键 词：膀胱癌 性激素 性激素受体 

分 类 号：R737.14[医药卫生—肿瘤]