癌症恶病质与肿瘤坏死因子关系的临床研究  

A Clinical Study of Cachexia and its Relationship to Tumor Necrosis Factor

作　　者：胡赤丁[1] 吴友胜[1] 徐秀琴 吴敬崇 姜富生[1] 吴永方[2] 

机构地区：[1]武汉职工医学院附院,430015 [2]武汉职工医学院肿瘤研究室

出　　处：《肿瘤防治研究》2000年第3期201-202,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　初步探讨肿瘤坏死因子 (TNF α)含量与癌症恶病质的关系。方法　用苯丙酸诺龙及营养支持疗法对 19例恶病质患者治疗三周 ,观察治疗前后患者血清中TNF α ,体重、右上臂中部周径、三头肌皮摺厚度 ,KPS评分、总蛋白、白蛋白的变化 ,并与 17例健康对照组进行比较。结果　疾病组治疗前TNF α值明显高于对照组 (P <0 0 1) ,治疗后TNF α值较治疗前明显下降 (P <0 0 1) ,并接近对照组 ,治疗后其余各项指标较治疗前均增加 ,病情好转时TNF α值是下降的。结论　TNF α可能是参与恶病质过程的重要细胞因子之一 。Objective To explore the association between tumor necrosis factor and cachexia.Methods 19 cancer patients with cachexia and 17 healthy individuals were treated with durobolin.Comparisons were made in the blood TNF α,TP,Alb,body weight and KPS,before and after treatment,between the two groups.Results The level of serum TNF α in cancer group was significantly higher than that of control group before treatment ( P <0 01).After treatment the level of serum TNF α was decreased as compare to the level before treatment( P <0 01).Conclusion The results suggested that the mechanism of cachexia may be related to TNF α.

关 键 词：肿瘤坏死因子 癌症恶病质 苯丙酸诺龙 

分 类 号：R730.231.9[医药卫生—肿瘤]